Literature DB >> 14718755

Fetal hypoxia is associated with elevated cord serum C-reactive protein levels in diabetic pregnancies.

Mikko Loukovaara1, Pekka Leinonen, Kari Teramo, Henrik Alfthan, Ulf-Håkan Stenman, Sture Andersson.   

Abstract

Maternal diabetes increases the risk of intrauterine hypoxia. Inflammation may play a role in the pathogenesis of hypoxia-related neonatal complications. We studied correlations between levels of cord serum C-reactive protein (CRP), measured by a highly sensitive immunofluorometric assay, and indices of fetal hypoxia in diabetic pregnancies. Cord serum CRP correlated positively with amniotic fluid erythropoietin and umbilical artery pCO2. A negative correlation existed between cord serum CRP and umbilical artery pH and pO2. Amniotic fluid erythropoietin showed an independent effect on cord serum CRP in multiple regression analysis. These data suggest that the fetus responds to hypoxia by an inflammatory reaction. Copyright 2004 S. Karger AG, Basel

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Year:  2004        PMID： 14718755     DOI： 10.1159/000076132

Source DB:  PubMed          Journal:  Biol Neonate        ISSN： 0006-3126


  7 in total

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Review 7.  Role of T-Cell Polarization and Inflammation and Their Modulation by n-3 Fatty Acids in Gestational Diabetes and Macrosomia.

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  7 in total

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