Literature DB >> 14718744

Role of matrix metalloproteinases in vascular remodeling.

Masafumi Kuzuya1, Akihisa Iguchi.   

Abstract

Vascular remodeling, defined as lasting structural changes in the vessel wall in response to hemodynamic stimuli, plays a role in many (patho)physiological processes requiring cell migration and degradation of extracellular matrix(ECM). Matrix metalloproteinase(MMP) system can degrade most ECM components. Several lines of evidence support a role for MMP system components in the development and progression of atherosclerosis and restenosis after angioplasty. This review article focuses on the role of MMPs in vascular remodeling relevant to atherosclerosis and restenosis after angioplasty.

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Year:  2003        PMID： 14718744     DOI： 10.5551/jat.10.275

Source DB:  PubMed          Journal:  J Atheroscler Thromb        ISSN： 1340-3478            Impact factor:   4.928


  29 in total

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