Literature DB >> 14718715

Alpha-synuclein haplotypes implicated in risk of Parkinson's disease.

E K Tan1, A Chai, Y Y Teo, Y Zhao, C Tan, H Shen, V R Chandran, M L Teoh, Y Yih, R Pavanni, M C Wong, K Puvan, Y L Lo, E Yap.   

Abstract

The authors examined four- and six-loci haplotype constructs (from five single nucleotide polymorphisms and three microsatellite regions) of the alpha-synuclein gene in patients with Parkinson's disease (PD) and controls in an ethnic Chinese population. Logistic regression analysis demonstrated an association of NACP-Rep1 (p = 0.002) and L478 (p < 0.0001) with risk of PD after correction for the effects of age, sex, and the other polymorphic loci. Specific four-loci and six-loci haplotypes were significantly associated with an increased or decreased risk of PD.

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Year:  2004        PMID： 14718715     DOI： 10.1212/01.wnl.0000101721.25345.dc

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  16 in total

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