Literature DB >> 14718633

Inhibition of human cytomegalovirus replication by small interfering RNAs.

Lüder Wiebusch1, Matthias Truss1, Christian Hagemeier1.   

Abstract

Small interfering RNAs (siRNAs) are the mediators of a sequence-specific process of gene silencing called RNA interference (RNAi). Here, we show that synthetic siRNAs against essential gene products of human cytomegalovirus (HCMV) can trigger RNAi in serum-starved, infected primary fibroblasts, as well as in U373 cells, leading to effective inhibition of viral DNA replication. This opens new possibilities for antiviral strategies and for the analysis of viral and cellular genes important to HCMV physiology.

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Year:  2004        PMID： 14718633     DOI： 10.1099/vir.0.19453-0

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  40 in total

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Review 2.  Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management.

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Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

3.  Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.

Authors:  Laura J Terry; Livia Vastag; Joshua D Rabinowitz; Thomas Shenk
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-06       Impact factor: 11.205

Review 4.  Cytomegalovirus antivirals and development of improved animal models.

Authors:  Alistair McGregor; K Yeon Choi
Journal:  Expert Opin Drug Metab Toxicol       Date:  2011-09-01       Impact factor: 4.481

5.  RNA interference-mediated targeting of human cytomegalovirus immediate-early or early gene products inhibits viral replication with differential effects on cellular functions.

Authors:  E Xiaofei; Bradford M Stadler; Michelle Debatis; Shixia Wang; Shan Lu; Timothy F Kowalik
Journal:  J Virol       Date:  2012-03-21       Impact factor: 5.103

6.  Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication.

Authors:  Blair L Strang; Steeve Boulant; Donald M Coen
Journal:  J Virol       Date:  2009-12-09       Impact factor: 5.103

7.  Effective inhibition in animals of viral pathogenesis by a ribozyme derived from RNase P catalytic RNA.

Authors:  Yong Bai; Phong Trang; Hongjian Li; Kihoon Kim; Tianhong Zhou; Fenyong Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-28       Impact factor: 11.205

8.  Human cytomegalovirus IE1-72 protein interacts with p53 and inhibits p53-dependent transactivation by a mechanism different from that of IE2-86 protein.

Authors:  Eung-Soo Hwang; Zhigang Zhang; Haobin Cai; David Y Huang; Shu-Mei Huong; Chang-Yong Cha; Eng-Shang Huang
Journal:  J Virol       Date:  2009-09-23       Impact factor: 5.103

9.  Efficient inhibition of human cytomegalovirus DNA polymerase expression by small hairpin RNA in vitro.

Authors:  Ran Tao; Miaofeng Hu; Qunjun Duan; Shiqiang Shang
Journal:  Curr Microbiol       Date:  2008-08-05       Impact factor: 2.188

10.  Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis.

Authors:  Zhikang Qian; Van Leung-Pineda; Baoqin Xuan; Helen Piwnica-Worms; Dong Yu
Journal:  PLoS Pathog       Date:  2010-03-19       Impact factor: 6.823
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