Literature DB >> 14718160

Old drugs, new tricks: using genetically sensitized yeast to reveal drug targets.

Tim Hughes1, Brenda Andrews, Charles Boone.   

Abstract

A study in this issue of Cell illustrates the power of applying genomic approaches with model systems to characterize the biological activity of small molecules and to identify their cellular targets, which can clarify the mode of action of human therapeutics.

Entities:  

Mesh：

Year:  2004        PMID： 14718160     DOI： 10.1016/s0092-8674(03)01070-5

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  5 in total

Review 1.  Bugs, drugs and chemical genomics.

Authors:  Terry Roemer; Julian Davies; Guri Giaever; Corey Nislow
Journal:  Nat Chem Biol       Date:  2011-12-15       Impact factor: 15.040

Review 2.  Exploiting drug-disease relationships for computational drug repositioning.

Authors:  Joel T Dudley; Tarangini Deshpande; Atul J Butte
Journal:  Brief Bioinform       Date:  2011-06-20       Impact factor: 11.622

3.  Evolutionary and Biochemical Aspects of Chemical Stress Resistance in Saccharomyces cerevisiae.

Authors:  Thiago Motta Venancio; Daniel Bellieny-Rabelo; L Aravind
Journal:  Front Genet       Date:  2012-03-30       Impact factor: 4.599

4.  Network-based inference methods for drug repositioning.

Authors:  Hailin Chen; Heng Zhang; Zuping Zhang; Yiqin Cao; Wenliang Tang
Journal:  Comput Math Methods Med       Date:  2015-04-12       Impact factor: 2.238

5.  A miRNA-driven inference model to construct potential drug-disease associations for drug repositioning.

Authors:  Hailin Chen; Zuping Zhang
Journal:  Biomed Res Int       Date:  2015-02-19       Impact factor: 3.411
  5 in total

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