| Literature DB >> 14717779 |
Sameena Iqbal1, Michael J R Jenner, Karin E Summers, Andrew J Davies, Janet Matthews, Andrew J Norton, Maria Calaminici, Ama Z Rohatiner, Jude Fitzgibbon, T Andrew Lister, Lindsey K Goff.
Abstract
The prognostic significance of IgH/Bcl2 rearrangement in follicular lymphoma (FL) remains contentious; polymerase chain reaction (PCR) methodology and tissue source variability may account for some inconsistencies. As IgH/Bcl2 major breakpoint region (MBR) sequences may be found in normal blood, an MBR+ result by conventional PCR in blood/bone marrow may not indicate FL. To establish tumour MBR status, 190 lymphoid tissue samples with histologically evident FL (and therefore >1% tumour cells) were examined by real-time quantifiable PCR; 50% (95/190) had clonal MBR IgH/Bcl2 (MBR was considered clonal when >1%). Overall survival (median = 11.5 years) of MBR+ and MBR- patients was not significantly different.Entities:
Mesh：
Substances：
Year: 2004 PMID： 14717779 DOI： 10.1046/j.1365-2141.2003.04796.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998