Steven C Cunningham1, David Shibata, Carmine Volpe. 1. Division of Surgical Oncology, Department of Surgery, University of Maryland Medical System, 22 South Greene Street, Baltimore, MD 21201, USA.
Abstract
BACKGROUND: Gastrointestinal stromal tumors (GIST) frequently recur even after complete resection. The typical pattern of failure from GISTs is both local and distant with hepatic and peritoneal metastases being most common. Isolated abdominal-wall recurrence from GISTs has not been previously described. AIM OF THE STUDY: To report an isolated abdominal-wound recurrence in the absence of widespread disease in a patient with GIST. METHODS: Case report of a GIST and isolated abdominal-wound recurrence after laparoscopic-assisted en bloc resection. RESULTS: Elderly male patient presented with an isolated abdominal wall incisional recurrence 18 mo after gastric resection and adjuvant imatinib mesylate therapy for a high-grade GIST. CONCLUSIONS: Complete resection of gastrointestinal stromal tumors followed by imatinib therapy may alter the extent of recurrence.
BACKGROUND:Gastrointestinal stromal tumors (GIST) frequently recur even after complete resection. The typical pattern of failure from GISTs is both local and distant with hepatic and peritoneal metastases being most common. Isolated abdominal-wall recurrence from GISTs has not been previously described. AIM OF THE STUDY: To report an isolated abdominal-wound recurrence in the absence of widespread disease in a patient with GIST. METHODS: Case report of a GIST and isolated abdominal-wound recurrence after laparoscopic-assisted en bloc resection. RESULTS: Elderly male patient presented with an isolated abdominal wall incisional recurrence 18 mo after gastric resection and adjuvant imatinib mesylate therapy for a high-grade GIST. CONCLUSIONS: Complete resection of gastrointestinal stromal tumors followed by imatinib therapy may alter the extent of recurrence.
Authors: D A Tuveson; N A Willis; T Jacks; J D Griffin; S Singer; C D Fletcher; J A Fletcher; G D Demetri Journal: Oncogene Date: 2001-08-16 Impact factor: 9.867
Authors: S Hirota; K Isozaki; Y Moriyama; K Hashimoto; T Nishida; S Ishiguro; K Kawano; M Hanada; A Kurata; M Takeda; G Muhammad Tunio; Y Matsuzawa; Y Kanakura; Y Shinomura; Y Kitamura Journal: Science Date: 1998-01-23 Impact factor: 47.728
Authors: George D Demetri; Margaret von Mehren; Charles D Blanke; Annick D Van den Abbeele; Burton Eisenberg; Peter J Roberts; Michael C Heinrich; David A Tuveson; Samuel Singer; Milos Janicek; Jonathan A Fletcher; Stuart G Silverman; Sandra L Silberman; Renaud Capdeville; Beate Kiese; Bin Peng; Sasa Dimitrijevic; Brian J Druker; Christopher Corless; Christopher D M Fletcher; Heikki Joensuu Journal: N Engl J Med Date: 2002-08-15 Impact factor: 91.245