| Literature DB >> 14716020 |
Hye-Youn Lee1, Maurice Kléber, Lisette Hari, Véronique Brault, Ueli Suter, Makoto M Taketo, Rolf Kemler, Lukas Sommer.
Abstract
Wnt signaling has recently emerged as a key factor in controlling stem cell expansion. In contrast, we show here that Wnt/beta-catenin signal activation in emigrating neural crest stem cells (NCSCs) has little effect on the population size and instead regulates fate decisions. Sustained beta-catenin activity in neural crest cells promotes the formation of sensory neural cells in vivo at the expense of virtually all other neural crest derivatives. Moreover, Wnt1 is able to instruct early NCSCs (eNCSCs) to adopt a sensory neuronal fate in a beta-catenin-dependent manner. Thus, the role of Wnt/beta-catenin in stem cells is cell-type dependent.Entities:
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Year: 2004 PMID： 14716020 DOI： 10.1126/science.1091611
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728