Literature DB >> 14715448

Effects of Sertoli cell transplants in a 3-nitropropionic acid model of early Huntington's disease: a preliminary study.

Alba I Rodriguez1, Alison E Willing, Samuel Saporta, Don F Cameron, Paul R Sanberg.   

Abstract

Problems with immunosuppression and graft survival limit clinical applications of neurotransplantation protocols for neurodegenerative disease. Sertoli cells, testes-derived cells with immunosuppressive and trophic properties, may serve as an alternative cell source for transplantation. Sertoli cells were transplanted into the striatum of rats following two injections of 3-nitropropionic acid (3-NP) to determine whether they could ameliorate abnormalities in a model of early stage Huntington's disease. 3-NP-induced locomotor hyperactivity was significantly reduced in rats receiving Sertoli transplants compared to controls, with some behaviors returning to baseline. Sertoli cells survived in the striatum without systemic immunosuppression and some formed tubule-like structures. These results show that Sertoli transplants are able to ameliorate locomotor abnormalities in a 3-NP model of early HD. Thus, Sertoli cells should be further evaluated as a possible treatment strategy for the early stages of Huntington's disease.

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Year:  2003        PMID： 14715448     DOI： 10.1007/bf03033174

Source DB:  PubMed          Journal:  Neurotox Res        ISSN： 1029-8428            Impact factor:   3.911


  36 in total

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2.  Vectorial production of interleukin 1 and interleukin 6 by rat Sertoli cells cultured in a dual culture compartment system.

Authors:  C Cudicini; H Kercret; A M Touzalin; F Ballet; B Jégou
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3.  Severe central-nervous-system toxicity associated with cyclosporin.

Authors:  J H Berden; A J Hoitsma; J L Merx; A Keyser
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4.  Effects of cool storage on survival and function of intrastriatal ventral mesencephalic grafts.

Authors:  H Sauer; P Brundin
Journal:  Restor Neurol Neurosci       Date:  1991-01-01       Impact factor: 2.406

5.  Hyperactivity and hypoactivity in a rat model of Huntington's disease: the systemic 3-nitropropionic acid model.

Authors:  C V Borlongan; T K Koutouzis; T B Freeman; R A Hauser; D W Cahill; P R Sanberg
Journal:  Brain Res Brain Res Protoc       Date:  1997-08

6.  Intracerebral transplantation of testis-derived sertoli cells promotes functional recovery in female rats with 6-hydroxydopamine-induced hemiparkinsonism.

Authors:  C V Borlongan; D F Cameron; S Saporta; P R Sanberg
Journal:  Exp Neurol       Date:  1997-11       Impact factor: 5.330

7.  Testis-derived Sertoli cells have a trophic effect on dopamine neurons and alleviate hemiparkinsonism in rats.

Authors:  P R Sanberg; C V Borlongan; A I Othberg; S Saporta; T B Freeman; D F Cameron
Journal:  Nat Med       Date:  1997-10       Impact factor: 53.440

8.  The testis-derived cultured Sertoli cell as a natural Fas-L secreting cell for immunosuppressive cellular therapy.

Authors:  P R Sanberg; S Saporta; C V Borlongan; A I Othberg; R C Allen; D F Cameron
Journal:  Cell Transplant       Date:  1997 Mar-Apr       Impact factor: 4.139

9.  Central nervous system toxicity after liver transplantation. The role of cyclosporine and cholesterol.

Authors:  P C de Groen; A J Aksamit; J Rakela; G S Forbes; R A Krom
Journal:  N Engl J Med       Date:  1987-10-01       Impact factor: 91.245

10.  Systemic 3-nitropropionic acid: long-term effects on locomotor behavior.

Authors:  T K Koutouzis; C V Borlongan; T Scorcia; I Creese; D W Cahill; T B Freeman; P R Sanberg
Journal:  Brain Res       Date:  1994-05-23       Impact factor: 3.252
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  11 in total

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Journal:  J Mol Neurosci       Date:  2018-04-21       Impact factor: 3.444

2.  Therapeutic Potential of Pretreatment with Allograft Sertoli Cells Transplantation in Brain Ischemia by Improving Oxidative Defenses.

Authors:  Sara Milanizadeh; Karrar Najm Najaf Zuwarali; Abbas Aliaghaei; Mohammad Reza Bigdeli
Journal:  J Mol Neurosci       Date:  2018-03-17       Impact factor: 3.444

Review 3.  The battle of the sexes for stroke therapy: female- versus male-derived stem cells.

Authors:  Yuji Kaneko; Travis Dailey; Nathan L Weinbren; Jessica Rizzi; Cyrus Tamboli; Julie G Allickson; Nicole Kuzmin-Nichols; Paul R Sanberg; David J Eve; Naoki Tajiri; Cesar V Borlongan
Journal:  CNS Neurol Disord Drug Targets       Date:  2013-05-01       Impact factor: 4.388

4.  Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease.

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Journal:  CNS Neurosci Ther       Date:  2016-05-26       Impact factor: 5.243

5.  Combined strategy of endothelial cells coating, Sertoli cells coculture and infusion improves vascularization and rejection protection of islet graft.

Authors:  Yang Li; Wujun Xue; Hongbao Liu; Ping Fan; Xiaohong Wang; Xiaoming Ding; Xiaohui Tian; Xinshun Feng; Xiaoming Pan; Jin Zheng; Puxun Tian; Chenguang Ding; Xiaohu Fan
Journal:  PLoS One       Date:  2013-02-20       Impact factor: 3.240

6.  Cilostazol disrupts TLR-4, Akt/GSK-3β/CREB, and IL-6/JAK-2/STAT-3/SOCS-3 crosstalk in a rat model of Huntington's disease.

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7.  Lentiviral transduction of rat Sertoli cells as a means to modify gene expression.

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Journal:  Spermatogenesis       Date:  2012-10-01

Review 8.  Sertoli cell grafts for Huntington's disease. An opinion.

Authors:  Dwaine F Emerich
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.978

Review 9.  Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. a review.

Authors:  Richard M Kostrzewa; Juan Segura-Aguilar
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.978

Review 10.  Adult stem cell transplantation: is gender a factor in stemness?

Authors:  Naoki Tajiri; Kelsey Duncan; Mia C Borlongan; Mibel Pabon; Sandra Acosta; Ike de la Pena; Diana Hernadez-Ontiveros; Diego Lozano; Daniela Aguirre; Stephanny Reyes; Paul R Sanberg; David J Eve; Cesar V Borlongan; Yuji Kaneko
Journal:  Int J Mol Sci       Date:  2014-08-28       Impact factor: 5.923
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