| Literature DB >> 1471539 |
T Fujimoto1, T Nakano, T Takano, Y Hokazono, T Asakura, T Tsuji.
Abstract
Phosphorus-31 chemical shift imaging showed regional abnormalities of in vivo 31P NMR spectra in the brains of chronic schizophrenic patients. In the left temporal region, the level of % phosphodiesters (PDE) was increased and the level of % gamma alpha beta-ATP (obtained by summation of gamma-ATP, alpha-ATP, and beta-ATP) was decreased. In the basal ganglia, the levels of % PDE were decreased and the level of % phosphomonoesters was increased. The levels of % gamma alpha beta-ATP were increased in the right basal ganglia. The level of % phosphocreatine was decreased in the frontoparietal region. These findings may represent different patterns of dysfunction of membrane phospholipid bilayers and high-energy phosphate metabolism in the specific cerebral regions.Entities:
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Year: 1992 PMID： 1471539 DOI： 10.1111/j.1600-0447.1992.tb03297.x
Source DB: PubMed Journal: Acta Psychiatr Scand ISSN： 0001-690X Impact factor: 6.392