| Literature DB >> 14714098 |
N G Kolosova1, P A Lebedev, S V Aidagulova, T S Morozkova.
Abstract
Changes in the lens appear by the age of 2 months in early aging OXYS rats, at the age of 6 months these changes are detected in 100% animals, and by 12 months both eyes are involved. According to biomicroscopy findings, predominant forms of cataract are vesicular, annular, and dendritic, located in the cortical layer and/or nucleus of the lens. Light and electron microscopy showed morphological changes involving all structural components of the lens: epithelial degeneration progressing with age, deformation of fiber architectonics, and appearance of uneven condensations. Cataract in OXYS rats corresponds to senile cataract, which makes this rat strain a unique model for studies of the pathogenesis of involutive cataract and elaboration of methods for its prevention and correction.Entities:
Mesh：
Year: 2003 PMID： 14714098 DOI： 10.1023/b:bebm.0000010967.24302.78
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804