| Literature DB >> 14714073 |
B A Umarova1, G N Kopylova, E A Smirnova, A A Guseva, S E Zhuikova.
Abstract
Stress increased secretory activity of mast cells in the mesentery and subcutaneous fat of rats. Intraperitoneal injection of Semax and prolyl-glycyl-proline in doses of 0.05 and 1 mg/kg, respectively, 1 h before stress abolished this effect. The test preparations did not modulate secretory activity of mast cells in unstressed animals. Semax and prolyl-glycyl-proline in vitro prevented activation of mast cells with synacten and acetylcholine. The stabilizing effect of peptides on mast cells probably determines their antiulcer activity.Entities:
Mesh：
Substances：
Year: 2003 PMID： 14714073 DOI： 10.1023/b:bebm.0000010942.14275.50
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804