OBJECTIVE: Advances in the understanding of sepsis have failed to deliver satisfactory new treatments aimed at attenuating inflammatory-mediated organ dysfunction. Phagocytic cells play a pivotal role in driving the inflammatory response and causing direct tissue injury. Adenoreceptor stimulation may attenuate such inflammatory-mediated damage by down-regulating phagocytic activity and preventing excessive respiratory burst activation. DATA: A Medline database was used to perform a literature search for all articles relating to the use of adenosine as an immunomodulatory agent. CONCLUSION: There is convincing evidence to suggest that adenoreceptor modulation can prevent tissue injury through a variety of pathways. The use of adenosine modulation in ischemia/reperfusion injury has been the subject of considerable investigation, although experience with its use in sepsis is limited.
OBJECTIVE: Advances in the understanding of sepsis have failed to deliver satisfactory new treatments aimed at attenuating inflammatory-mediated organ dysfunction. Phagocytic cells play a pivotal role in driving the inflammatory response and causing direct tissue injury. Adenoreceptor stimulation may attenuate such inflammatory-mediated damage by down-regulating phagocytic activity and preventing excessive respiratory burst activation. DATA: A Medline database was used to perform a literature search for all articles relating to the use of adenosine as an immunomodulatory agent. CONCLUSION: There is convincing evidence to suggest that adenoreceptor modulation can prevent tissue injury through a variety of pathways. The use of adenosine modulation in ischemia/reperfusion injury has been the subject of considerable investigation, although experience with its use in sepsis is limited.
Authors: F Gloria-Bottini; M Banci; P Saccucci; N Lucarini; F Ianniello; G Paradisi; A Magrini; E Bottini Journal: Cardiol Res Pract Date: 2010-04-13 Impact factor: 1.866
Authors: Melanie L Hart; Martina Henn; David Köhler; Doris Kloor; Michel Mittelbronn; Iris C Gorzolla; Gregory L Stahl; Holger K Eltzschig Journal: FASEB J Date: 2008-03-19 Impact factor: 5.191
Authors: Peter M Milano; Christelle D Douillet; Paul J Riesenman; William P Robinson; Stephanie K Beidler; Ben L Zarzaur; Preston B Rich Journal: J Surg Res Date: 2007-08-03 Impact factor: 2.192