| Literature DB >> 14706840 |
Hans A R Bluyssen1, Martijn P J K Lolkema, Moniek van Beest, Michelle Boone, Cristel M J T Snijckers, Maartje Los, Martijn F B G Gebbink, Branko Braam, Frank C P Holstege, Rachel H Giles, Emile E Voest.
Abstract
The von Hippel-Lindau (VHL) tumor suppressor gene regulates the extracellular matrix by controlling fibronectin deposition. To identify novel VHL target genes, we subjected mRNA from VHL-deficient RCC cells (786-0-pRC) and a transfectant re-expressing wildtype VHL (786-0-VHL) to differential expression profiling. Among the differentially expressed genes, we detected that fibronectin is upregulated in the presence of VHL, while it is not affected by hypoxia. Thus regulation of fibronectin deposition by VHL occurs at the transcriptional level, irrespective of oxygen levels.Entities:
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Year: 2004 PMID： 14706840 DOI： 10.1016/s0014-5793(03)01392-9
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124