OBJECTIVE: To investigate the nature of differing recruitment rates for clinical treatment trials for anorexia nervosa and bulimia nervosa. METHODS: Recruitment rates from a study recruiting women partially recovered from anorexia nervosa were compared with the rates from two studies conducted at the same sites recruiting women with bulimia nervosa. RESULTS: At all sites in the anorexia study, the total number of contacts per month rose steadily over the first 2 years of the recruitment phase then decreased to near zero with the number of participants randomized to the study practically evaporating. In contrast, the bulimia studies screened a larger group of contacts and met monthly randomization goals in the time allotted for recruitment. Participants eligible for a study but with a barrier to participation occurred at a much higher rate in the anorexia study than in the bulimia studies. DISCUSSION: These results reveal a difficulty in planning recruitment from a small population such as partially recovered anorexics. A small population's total pool size diminishes faster than it is replenished, suggesting that future studies of anorexia nervosa may recruit more successfully from many sites in a short period rather than at a few sites over a long period. Copyright 2003 by Wiley Periodicals, Inc. Int J Eat Disord 35: 33-41, 2004.
RCT Entities:
OBJECTIVE: To investigate the nature of differing recruitment rates for clinical treatment trials for anorexia nervosa and bulimia nervosa. METHODS: Recruitment rates from a study recruiting women partially recovered from anorexia nervosa were compared with the rates from two studies conducted at the same sites recruiting women with bulimia nervosa. RESULTS: At all sites in the anorexia study, the total number of contacts per month rose steadily over the first 2 years of the recruitment phase then decreased to near zero with the number of participants randomized to the study practically evaporating. In contrast, the bulimia studies screened a larger group of contacts and met monthly randomization goals in the time allotted for recruitment. Participants eligible for a study but with a barrier to participation occurred at a much higher rate in the anorexia study than in the bulimia studies. DISCUSSION: These results reveal a difficulty in planning recruitment from a small population such as partially recovered anorexics. A small population's total pool size diminishes faster than it is replenished, suggesting that future studies of anorexia nervosa may recruit more successfully from many sites in a short period rather than at a few sites over a long period. Copyright 2003 by Wiley Periodicals, Inc. Int J Eat Disord 35: 33-41, 2004.
Authors: Lisa Brownstone; Kristen Anderson; Judy Beenhakker; James Lock; Daniel Le Grange Journal: Int J Eat Disord Date: 2012-03-12 Impact factor: 4.861
Authors: Katharine L Loeb; Ruth Striegel Weissman; Sue Marcus; Cassandra Pattanayak; Lisa Hail; Kelly C Kung; Diana Schron; Nancy Zucker; Daniel Le Grange; James Lock; Jeffrey H Newcorn; C Barr Taylor; B Timothy Walsh Journal: Front Psychiatry Date: 2020-01-22 Impact factor: 4.157