| Literature DB >> 14704790 |
Rolf Göggel1, Supandi Winoto-Morbach, Gabriele Vielhaber, Yumiko Imai, Karsten Lindner, Lore Brade, Helmut Brade, Stefan Ehlers, Arthur S Slutsky, Stefan Schütze, Erich Gulbins, Stefan Uhlig.
Abstract
Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the cyclooxygenase pathway. Agents that interfere with PAF-induced ceramide synthesis, such as steroids or the xanthogenate D609, attenuate pulmonary edema formation induced by PAF, endotoxin or acid instillation. Our results identify acid sphingomyelinase and ceramide as possible therapeutic targets in acute lung injury.Entities:
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Year: 2004 PMID： 14704790 DOI： 10.1038/nm977
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440