Literature DB >> 14703361

Enantioselective preparation of the C1-C11 fragment of apoptolidin.

William D Paquette1, Richard E Taylor.   

Abstract

[reaction: see text] A novel approach toward the synthesis of the triene portion of the biologically active polyketide apoptolidin is described. The use of an iterative thionyl chloride rearrangement/oxidation sequence to construct trisubstituted olefins is explored.

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Year:  2004        PMID： 14703361     DOI： 10.1021/ol0361397

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  A stereoselective synthesis of (+)-herboxidiene/GEX1A.

Authors:  Arun K Ghosh; Jianfeng Li
Journal:  Org Lett       Date:  2010-12-02       Impact factor: 6.005

2.  Apoptolidins B and C: isolation, structure determination, and biological activity.

Authors:  Paul A Wender; Martin Sukopp; Kate Longcore
Journal:  Org Lett       Date:  2005-07-07       Impact factor: 6.005

3.  Evolution of the total synthesis of (-)-okilactomycin exploiting a tandem oxy-cope rearrangement/oxidation, a Petasis-Ferrier union/rearrangement, and ring-closing metathesis.

Authors:  Amos B Smith; Todd Bosanac; Kallol Basu
Journal:  J Am Chem Soc       Date:  2009-02-18       Impact factor: 15.419

4.  Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues.

Authors:  Paul A Wender; Orion D Jankowski; Kate Longcore; Elie A Tabet; Haruo Seto; Taijiro Tomikawa
Journal:  Org Lett       Date:  2006-02-16       Impact factor: 6.005

5.  Total synthesis of apoptolidin A.

Authors:  Michael T Crimmins; Hamish S Christie; Alan Long; Kleem Chaudhary
Journal:  Org Lett       Date:  2009-02-19       Impact factor: 6.005

6.  Synthesis and evaluation of the cytotoxicity of apoptolidinones A and D.

Authors:  Victor P Ghidu; Jingqi Wang; Bin Wu; Qingsong Liu; Aaron Jacobs; Lawrence J Marnett; Gary A Sulikowski
Journal:  J Org Chem       Date:  2008-06-11       Impact factor: 4.354
  6 in total

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