Literature DB >> 1470223

Pituitary adenylate cyclase activating peptide, a novel VIP-like gut-brain peptide, relaxes the guinea-pig taenia caeci via apamin-sensitive potassium channels.

H Schwörer1, S Katsoulis, W Creutzfeldt, W E Schmidt.   

Abstract

Effects of pituitary adenylate cyclase activating peptide (PACAP-(1-27)) and vasoactive intestinal polypeptide (VIP) on the guinea-pig taenia caeci were studied in the presence of guanethidine and scopolamine. Both peptides (1 nmol/1-1 mumol/l) concentration-dependently relaxed the smooth muscle of the taenia. PACAP-(1-27) and VIP were nearly equipotent. Apamin (30 nmol/l), a selective blocker of calcium-activated potassium channels, abolished the relaxation induced by PACAP-(1-27) whereas the effect of VIP remained unaffected. PACAP-(1-27) may be a candidate for the noncholinergic, non-adrenergic inhibitory neurotransmitter which induces apamin-sensitive relaxation in the intestinal tract.

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Year:  1992        PMID： 1470223     DOI： 10.1007/bf00169005

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  13 in total

1.  Apamin blocks certain neurotransmitter-induced increases in potassium permeability.

Authors:  B E Banks; C Brown; G M Burgess; G Burnstock; M Claret; T M Cocks; D H Jenkinson
Journal:  Nature       Date:  1979-11-22       Impact factor: 49.962

2.  Two high affinity binding sites for pituitary adenylate cyclase-activating polypeptide have different tissue distributions.

Authors:  B D Shivers; T J Görcs; P E Gottschall; A Arimura
Journal:  Endocrinology       Date:  1991-06       Impact factor: 4.736

Review 3.  Peptide toxins and potassium channels.

Authors:  F Dreyer
Journal:  Rev Physiol Biochem Pharmacol       Date:  1990       Impact factor: 5.545

4.  Characterization of a guanosine-nucleotide-binding-protein-coupled receptor for pituitary adenylate-cyclase-activating polypeptide on plasma membranes from rat brain.

Authors:  H Schäfer; R Schwarzhoff; W Creutzfeldt; W E Schmidt
Journal:  Eur J Biochem       Date:  1991-12-18

5.  Prejunctional inhibition of vasoactive intestinal peptide release.

Authors:  J R Grider; G M Makhlouf
Journal:  Am J Physiol       Date:  1987-07

6.  The effect of apamin on the smooth muscle cells of the guinea-pig taenia coli.

Authors:  A J Maas; A Den Hertog
Journal:  Eur J Pharmacol       Date:  1979-09-15       Impact factor: 4.432

7.  Apamin distinguishes two types of relaxation mediated by enteric nerves in the guinea-pig gastrointestinal tract.

Authors:  M Costa; J B Furness; C M Humphreys
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-01       Impact factor: 3.000

8.  Pituitary adenylate cyclase activating peptide: a novel vasoactive intestinal peptide-like neuropeptide in the gut.

Authors:  F Sundler; E Ekblad; A Absood; R Håkanson; K Köves; A Arimura
Journal:  Neuroscience       Date:  1992       Impact factor: 3.590

9.  Vasoactive intestinal polypeptide induces neurogenic contraction of guinea-pig ileum. Involvement of acetylcholine and substance P.

Authors:  S Katsoulis; W E Schmidt; A Clemens; H Schwörer; W Creutzfeldt
Journal:  Regul Pept       Date:  1992-03-19

10.  Study on the possible neurotransmitter of the non-adrenergic non-cholinergic innervation of the rat gastric fundus.

Authors:  R A Lefebvre
Journal:  Arch Int Pharmacodyn Ther       Date:  1986-04
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  15 in total

1.  VIP- and PACAP-mediated nonadrenergic, noncholinergic inhibition in longitudinal muscle of rat distal colon: involvement of activation of charybdotoxin- and apamin-sensitive K+ channels.

Authors:  M Kishi; T Takeuchi; N Suthamnatpong; T Ishii; H Nishio; F Hata; T Takewaki
Journal:  Br J Pharmacol       Date:  1996-10       Impact factor: 8.739

2.  Evidence that nitric oxide acts as an inhibitory neurotransmitter supplying taenia from the guinea-pig caecum.

Authors:  C W Shuttleworth; K M Sweeney; K M Sanders
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

3.  The possible role of ATP and PACAP as mediators of apaminsensitive NANC inhibitory junction potentials in circular muscle of guinea-pig colon.

Authors:  V Zagorodnyuk; P Santicioli; C A Maggi; A Giachetti
Journal:  Br J Pharmacol       Date:  1996-11       Impact factor: 8.739

4.  Central effects of pituitary adenylate cyclase activating polypeptide (PACAP) on gastric motility and emptying in rats.

Authors:  M Ozawa; M Aono; M Moriga
Journal:  Dig Dis Sci       Date:  1999-04       Impact factor: 3.199

5.  PACAP Modulates Acetylcholine-Elicited Contractions at Nicotinic Neuromuscular Contacts of the Land Snail.

Authors:  Nóra Krajcs; László Hernádi; Zsolt Pirger; Dóra Reglődi; Gábor Tóth; Tibor Kiss
Journal:  J Mol Neurosci       Date:  2015-07-03       Impact factor: 3.444

6.  Stimulant action of pituitary adenylate cyclase-activating peptide on normal and drug-compromised peristalsis in the guinea-pig intestine.

Authors:  A Heinemann; P Holzer
Journal:  Br J Pharmacol       Date:  1999-06       Impact factor: 8.739

7.  Electrophysiological analysis of the actions of pituitary adenylyl cyclase activating peptide in the taenia of the guinea-pig caecum.

Authors:  K McConalogue; D J Lyster; J B Furness
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-11       Impact factor: 3.000

8.  Apamin- and nitric oxide-sensitive biphasic non-adrenergic non-cholinergic inhibitory junction potentials in the rat anococcygeus muscle.

Authors:  S Selemidis; J Ziogas; T M Cocks
Journal:  J Physiol       Date:  1998-12-15       Impact factor: 5.182

9.  Tyrosine kinase involvement in apamin-sensitive inhibitory responses of rat distal colon.

Authors:  T Takeuchi; M Kishi; N Hirayama; M Yamaji; T Ishii; H Nishio; F Hata; T Takewaki
Journal:  J Physiol       Date:  1999-01-01       Impact factor: 5.182

10.  Distribution and effects of pituitary adenylate cyclase activating peptide in cat and human lower oesophageal sphincter.

Authors:  L Ny; B Larsson; P Alm; P Ekström; J Fahrenkrug; J Hannibal; K E Andersson
Journal:  Br J Pharmacol       Date:  1995-12       Impact factor: 8.739
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