Literature DB >> 14702101

VEGF: a critical player in neurodegeneration.

Erik Storkebaum1, Peter Carmeliet.   

Abstract

VEGF is a prototype angiogenic factor, but recent evidence indicates that this growth factor also has direct effects on neural cells. Abnormal regulation of VEGF expression has now been implicated in several neurodegenerative disorders, including motoneuron degeneration. This has stimulated an increasing interest in assessing the therapeutic potential of VEGF as a neuroprotective agent for such neurodegenerative disorders.

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Year:  2004        PMID： 14702101      PMCID： PMC300888          DOI： 10.1172/JCI20682

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  51 in total

1.  Postnatal expression of VEGF and its receptor flk-1 in peripheral ganglia.

Authors:  M Sondell; M Kanje
Journal:  Neuroreport       Date:  2001-01-22       Impact factor: 1.837

2.  Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades.

Authors:  H Matsuzaki; M Tamatani; A Yamaguchi; K Namikawa; H Kiyama; M P Vitek; N Mitsuda; M Tohyama
Journal:  FASEB J       Date:  2001-05       Impact factor: 5.191

Review 3.  Angiogenesis in health and disease.

Authors:  Peter Carmeliet
Journal:  Nat Med       Date:  2003-06       Impact factor: 53.440

4.  Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats.

Authors:  J E Black; K R Isaacs; B J Anderson; A A Alcantara; W T Greenough
Journal:  Proc Natl Acad Sci U S A       Date:  1990-07       Impact factor: 11.205

5.  Focal reductions of cerebral blood flow in amyotrophic lateral sclerosis: a [99mTc]-d,l-HMPAO SPECT study.

Authors:  G Waldemar; S Vorstrup; T S Jensen; A Johnsen; G Boysen
Journal:  J Neurol Sci       Date:  1992-01       Impact factor: 3.181

Review 6.  Effect of age on cerebral blood flow: measurement with ungated two-dimensional phase-contrast MR angiography in 250 adults.

Authors:  P C Buijs; M J Krabbe-Hartkamp; C J Bakker; E E de Lange; L M Ramos; M M Breteler; W P Mali
Journal:  Radiology       Date:  1998-12       Impact factor: 11.105

7.  Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

Authors:  B Oosthuyse; L Moons; E Storkebaum; H Beck; D Nuyens; K Brusselmans; J Van Dorpe; P Hellings; M Gorselink; S Heymans; G Theilmeier; M Dewerchin; V Laudenbach; P Vermylen; H Raat; T Acker; V Vleminckx; L Van Den Bosch; N Cashman; H Fujisawa; M R Drost; R Sciot; F Bruyninckx; D J Hicklin; C Ince; P Gressens; F Lupu; K H Plate; W Robberecht; J M Herbert; D Collen; P Carmeliet
Journal:  Nat Genet       Date:  2001-06       Impact factor: 38.330

8.  Improvement in chronic ischemic neuropathy after intramuscular phVEGF165 gene transfer in patients with critical limb ischemia.

Authors:  D Simovic; J M Isner; A H Ropper; A Pieczek; D H Weinberg
Journal:  Arch Neurol       Date:  2001-05

9.  VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death.

Authors:  Diether Lambrechts; Erik Storkebaum; Masafumi Morimoto; Jurgen Del-Favero; Frederik Desmet; Stefan L Marklund; Sabine Wyns; Vincent Thijs; Jörgen Andersson; Ingrid van Marion; Ammar Al-Chalabi; Stephanie Bornes; Rhiannon Musson; Valerie Hansen; Lars Beckman; Rolf Adolfsson; Hardev Singh Pall; Hervé Prats; Severine Vermeire; Paul Rutgeerts; Shigehiro Katayama; Takuya Awata; Nigel Leigh; Loïc Lang-Lazdunski; Mieke Dewerchin; Christopher Shaw; Lieve Moons; Robert Vlietinck; Karen E Morrison; Wim Robberecht; Christine Van Broeckhoven; Désiré Collen; Peter M Andersen; Peter Carmeliet
Journal:  Nat Genet       Date:  2003-08       Impact factor: 38.330

10.  VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia.

Authors:  Yunjuan Sun; Kunlin Jin; Lin Xie; Jocelyn Childs; Xiao Ou Mao; Anna Logvinova; David A Greenberg
Journal:  J Clin Invest       Date:  2003-06       Impact factor: 14.808
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  69 in total

1.  Surgical angiogenesis modifies the cellular environment of nerve allografts in a rat sciatic nerve defect model.

Authors:  Tiam M Saffari; Amr Badreldin; Femke Mathot; Leila Bagheri; Allen T Bishop; Andre J van Wijnen; Alexander Y Shin
Journal:  Gene       Date:  2020-04-27       Impact factor: 3.688

2.  Quantification of vascular endothelial growth factor and neuropilins mRNAs during rat brain maturation by real-time PCR.

Authors:  Soraya Adris; Elizabeth Ojeda; Mario Genero; Pablo Argibay
Journal:  Cell Mol Neurobiol       Date:  2005-09       Impact factor: 5.046

3.  VEGF and seizures: cross-talk between endothelial and neuronal environments.

Authors:  Annamaria Vezzani
Journal:  Epilepsy Curr       Date:  2005 Mar-Apr       Impact factor: 7.500

Review 4.  Role of platelet-derived growth factors in physiology and medicine.

Authors:  Johanna Andrae; Radiosa Gallini; Christer Betsholtz
Journal:  Genes Dev       Date:  2008-05-15       Impact factor: 11.361

5.  No association of VEGF polymorphims with Alzheimer's disease.

Authors:  Sara Landgren; Mona Seibt Palmér; Ingemar Skoog; Lennart Minthon; Anders Wallin; Niels Andreasen; Madeleine Zetterberg; Kaj Blennow; Henrik Zetterberg
Journal:  Neuromolecular Med       Date:  2009-10-20       Impact factor: 3.843

6.  Sustained delivery of VEGF maintains innervation and promotes reperfusion in ischemic skeletal muscles via NGF/GDNF signaling.

Authors:  Dmitry Shvartsman; Hannah Storrie-White; Kangwon Lee; Cathal Kearney; Yevgeny Brudno; Nhi Ho; Christine Cezar; Corey McCann; Erin Anderson; John Koullias; Juan Carlos Tapia; Herman Vandenburgh; Jeff W Lichtman; David J Mooney
Journal:  Mol Ther       Date:  2014-04-28       Impact factor: 11.454

Review 7.  Molecular parallels between neural and vascular development.

Authors:  Anne Eichmann; Jean-Léon Thomas
Journal:  Cold Spring Harb Perspect Med       Date:  2013-01-01       Impact factor: 6.915

Review 8.  ω-3 and ω-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases.

Authors:  Yan Gong; Zhongjie Fu; Raffael Liegl; Jing Chen; Ann Hellström; Lois Eh Smith
Journal:  Am J Clin Nutr       Date:  2017-05-17       Impact factor: 7.045

9.  Transplantation of adult neural progenitor cells transfected with vascular endothelial growth factor rescues grafted cells in the rat brain.

Authors:  Martin H Maurer; Christine Thomas; Heinrich F Bürgers; Wolfgang Kuschinsky
Journal:  Int J Biol Sci       Date:  2007-12-03       Impact factor: 6.580

10.  An integral approach to the etiopathogenesis of human neurodegenerative diseases (HNDDs) and cancer. Possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (TFWS).

Authors:  Salvador Harguindey; Gorka Orive; Ramón Cacabelos; Enrique Meléndez Hevia; Ramón Díaz de Otazu; Jose Luis Arranz; Eduardo Anitua
Journal:  Neuropsychiatr Dis Treat       Date:  2008-12       Impact factor: 2.570
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