OBJECTIVE: Second-generation antipsychotics may enhance the rehabilitation of individuals with schizophrenia. The authors hypothesized that clients receiving second-generation antipsychotics would use vocational rehabilitation services more effectively and would have better employment outcomes than those receiving first-generation antipsychotics. METHODS: Ninety unemployed clients with schizophrenia and related disorders who were beginning a vocational rehabilitation program were followed for nine months. Three groups were defined according to the medication in use at study entry: olanzapine (N=39), risperidone (N=27), or first-generation antipsychotics only (N=24). Participants were interviewed monthly. RESULTS: The olanzapine and risperidone groups did not differ on any employment outcomes. On most vocational indicators, clients receiving second-generation agents did not differ from those receiving first-generation agents. However, at nine months the second-generation group had a significantly higher rate of participation in vocational training; a trend was found toward a higher rate of paid employment. All groups showed substantial improvement in employment outcomes after entering a vocational program. CONCLUSIONS: The hypothesis that second-generation antipsychotics promote better employment outcomes than first-generation antipsychotics was not upheld. However, second-generation agents appear to be associated with increased participation in vocational rehabilitation.
OBJECTIVE: Second-generation antipsychotics may enhance the rehabilitation of individuals with schizophrenia. The authors hypothesized that clients receiving second-generation antipsychotics would use vocational rehabilitation services more effectively and would have better employment outcomes than those receiving first-generation antipsychotics. METHODS: Ninety unemployed clients with schizophrenia and related disorders who were beginning a vocational rehabilitation program were followed for nine months. Three groups were defined according to the medication in use at study entry: olanzapine (N=39), risperidone (N=27), or first-generation antipsychotics only (N=24). Participants were interviewed monthly. RESULTS: The olanzapine and risperidone groups did not differ on any employment outcomes. On most vocational indicators, clients receiving second-generation agents did not differ from those receiving first-generation agents. However, at nine months the second-generation group had a significantly higher rate of participation in vocational training; a trend was found toward a higher rate of paid employment. All groups showed substantial improvement in employment outcomes after entering a vocational program. CONCLUSIONS: The hypothesis that second-generation antipsychotics promote better employment outcomes than first-generation antipsychotics was not upheld. However, second-generation agents appear to be associated with increased participation in vocational rehabilitation.
Authors: Barbara A Cornblatt; Ricardo E Carrión; Jean Addington; Larry Seidman; Elaine F Walker; Tyronne D Cannon; Kristin S Cadenhead; Thomas H McGlashan; Diana O Perkins; Ming T Tsuang; Scott W Woods; Robert Heinssen; Todd Lencz Journal: Schizophr Bull Date: 2011-11-10 Impact factor: 9.306
Authors: Sandra G Resnick; Robert A Rosenheck; Jose M Canive; Cyril De Souza; T Scott Stroup; Joseph McEvoy; Sonia Davis; Richard S E Keefe; Marvin Swartz; Jeffrey Lieberman Journal: J Behav Health Serv Res Date: 2008-02-02 Impact factor: 1.505
Authors: Luis Alameda; Philippe Golay; Philipp S Baumann; Pierre Progin; Nadir Mebdouhi; Julien Elowe; Carina Ferrari; Kim Q Do; Philippe Conus Journal: Schizophr Bull Date: 2017-09-01 Impact factor: 9.306
Authors: Barbara A Cornblatt; Andrea M Auther; Tara Niendam; Christopher W Smith; Jamie Zinberg; Carrie E Bearden; Tyrone D Cannon Journal: Schizophr Bull Date: 2007-04-17 Impact factor: 9.306