| Literature DB >> 14698864 |
Kakuri M Omari1, Raymond Chui, Katerina Dorovini-Zis.
Abstract
beta-chemokines play an important role during the course of central nervous system (CNS) inflammation. Using primary cultures of human cerebral microvascular endothelial cells, we detected increased monocyte chemoattractant protein-1 (MCP-1) and regulated upon activation normal T cell expressed and secreted (RANTES) production following incubation with soluble CD40L. These results suggest a potential mechanism by which activated CD40L positive T cells may enhance beta-chemokine expression and thus influence the recruitment of mononuclear cells across the human blood-brain barrier.Entities:
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Year: 2004 PMID： 14698864 DOI： 10.1016/j.jneuroim.2003.10.032
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478