| Literature DB >> 14698857 |
Karen M Palaszynski1, Kyi Kyi Loo, Judith F Ashouri, Hong-biao Liu, Rhonda R Voskuhl.
Abstract
A gender difference prevails in some murine strains of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis (MS). Our results showed that castration of SJL males, a strain characterized by decreased susceptibility of males as compared to females, displayed increased disease severity. In contrast, castration had no effect on disease in C57BL/6 males, a strain in which no gender difference in EAE is observed. Regardless of whether endogenous androgens were protective in a given genetic background, supplemental androgen treatment was protective in gonadally intact males of both strains. These data provide a basis for the novel therapeutic use of supplemental testosterone for men with MS.Entities:
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Year: 2004 PMID： 14698857 DOI： 10.1016/j.jneuroim.2003.11.004
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478