Literature DB >> 14698705

Compliance and satisfaction with switching from an immediate-release to sustained-release formulation of valproate in people with epilepsy.

Julie Doughty1, Gus A Baker, Ann Jacoby, Virginie Lavaud.   

Abstract

OBJECTIVE: The goal of our work was to assess compliance and patient satisfaction with switching from sodium valproate to Depakine Chrono in patients with epilepsy.
METHODS: Clinical, demographic, and behavioral details assessing compliance and satisfaction were collected using self-completion questionnaires at the time of inclusion in the study and 3 months after the inclusion day.
RESULTS: Data were collected from 2031 respondents from eight European countries. There were significant differences between time 1 and time 2 of the study in seizure frequency, reported side effects, compliance, and patient satisfaction.
CONCLUSION: Findings suggest that switching from sodium valproate to Depakine Chrono results in an increase in seizure-free rates, a reduction in reported side effects, an improvement in the level of compliance, and a modest improvement in patient satisfaction.

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Year:  2003        PMID: 14698705     DOI: 10.1016/j.yebeh.2003.08.013

Source DB:  PubMed          Journal:  Epilepsy Behav        ISSN: 1525-5050            Impact factor:   2.937


  16 in total

1.  [Compliance with medication in epilepsy. Reply to the comments of Stefan H (2008) Nervenarzt 79:1446-1447].

Authors:  Ulrich Specht
Journal:  Nervenarzt       Date:  2009-02       Impact factor: 1.214

2.  Extended-release formulations of antiepileptic drugs: rationale and comparative value.

Authors:  Emilio Perucca
Journal:  Epilepsy Curr       Date:  2009 Nov-Dec       Impact factor: 7.500

3.  Conventional and sustained-release valproate in children with newly diagnosed epilepsy: a randomized and crossover study comparing clinical effects, patient preference and pharmacokinetics.

Authors:  José L Herranz; Rosa Arteaga; Javier Adín; Juan A Armijo
Journal:  Eur J Clin Pharmacol       Date:  2006-08-02       Impact factor: 2.953

4.  Preparation of Coated Valproic Acid and Sodium Valproate Sustained-release Matrix Tablets.

Authors:  T Phaechamud; W Mueannoom; S Tuntarawongsa; S Chitrattha
Journal:  Indian J Pharm Sci       Date:  2010-03       Impact factor: 0.975

Review 5.  Extended-release formulations for the treatment of epilepsy.

Authors:  Meir Bialer
Journal:  CNS Drugs       Date:  2007       Impact factor: 5.749

6.  Divalproex to divalproex extended release conversion.

Authors:  Sandeep Dutta; Ronald C Reed
Journal:  Clin Drug Investig       Date:  2004       Impact factor: 2.859

Review 7.  A Clinician's Guide to Oral Extended-Release Drug Delivery Systems in Epilepsy.

Authors:  James W Wheless; Stephanie J Phelps
Journal:  J Pediatr Pharmacol Ther       Date:  2018 Jul-Aug

8.  Difficult to swallow: patient preferences for alternative valproate pharmaceutical formulations.

Authors:  Monali Bhosle; Joshua S Benner; Mitch Dekoven; Jeff Shelton
Journal:  Patient Prefer Adherence       Date:  2009-11-03       Impact factor: 2.711

9.  Comparative in vivo bioequivalence and in vitro dissolution of two valproic acid sustained-release formulations.

Authors:  Akira Fujii; Norio Yasui-Furukori; Taku Nakagami; Takenori Niioka; Manabu Saito; Yasushi Sato; Sunao Kaneko
Journal:  Drug Des Devel Ther       Date:  2009-02-06       Impact factor: 4.162

10.  Dosing frequency and adherence in chronic psychiatric disease: systematic review and meta-analysis.

Authors:  Goran Medic; Kyoko Higashi; Kavi J Littlewood; Teresa Diez; Ola Granström; René S Kahn
Journal:  Neuropsychiatr Dis Treat       Date:  2013-01-16       Impact factor: 2.570

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