Literature DB >> 14698680

Microinjection of CART peptide 55-102 into the nucleus accumbens blocks amphetamine-induced locomotion.

J-H Kim1, E Creekmore, P Vezina.   

Abstract

The role played by the biologically active CART 55-102 peptide in NAcc AMPH induced locomotion was investigated. When microinjected alone into this site, none of the doses of CART 55-102 tested (0.1, 0.4, 1.0 or 2.5 microg/0.5 microl/side) produced effects on locomotion during a two-h test. However, when co-injected with AMPH (2.5 microg/0.5 microl/side) into the NAcc, moderately high (2.5 microg/side) and middle to high (0.4-2.5 microg/side) doses of CART 55-102 significantly attenuated the effects of AMPH on locomotion and rearing, respectively. These results indicate that CART peptides can exert an antagonistic effect on the generation of locomotion by AMPH in the NAcc.

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Year:  2003        PMID： 14698680     DOI： 10.1016/j.npep.2003.10.001

Source DB:  PubMed          Journal:  Neuropeptides        ISSN： 0143-4179            Impact factor:   3.286


  27 in total

1.  Chromatin immunoprecipitation assays revealed CREB and serine 133 phospho-CREB binding to the CART gene proximal promoter.

Authors:  George A Rogge; Li-Ling Shen; Michael J Kuhar
Journal:  Brain Res       Date:  2010-05-06       Impact factor: 3.252

2.  CART peptide inhibits locomotor activity induced by simultaneous stimulation of D1 and D2 receptors, but not by stimulation of individual dopamine receptors.

Authors:  Mark C Moffett; Jane Song; Michael J Kuhar
Journal:  Synapse       Date:  2011-01       Impact factor: 2.562

3.  CART peptide in the nucleus accumbens regulates psychostimulants: Correlations between psychostimulant and CART peptide effects.

Authors:  Martin O Job; Michael J Kuhar
Journal:  Neuroscience       Date:  2017-02-16       Impact factor: 3.590

Review 4.  CART peptides: regulators of body weight, reward and other functions.

Authors:  G Rogge; D Jones; G W Hubert; Y Lin; M J Kuhar
Journal:  Nat Rev Neurosci       Date:  2008-10       Impact factor: 34.870

5.  Intra-accumbal administration of shRNAs against CART peptides cause increases in body weight and cocaine-induced locomotor activity in rats.

Authors:  M O Job; J Licata; G W Hubert; M J Kuhar
Journal:  Brain Res       Date:  2012-09-11       Impact factor: 3.252

6.  Reduced ethanol consumption and preference in cocaine- and amphetamine-regulated transcript (CART) knockout mice.

Authors:  Armando G Salinas; Chinh T Q Nguyen; Dara Ahmadi-Tehrani; Richard A Morrisett
Journal:  Addict Biol       Date:  2012-07-24       Impact factor: 4.280

7.  Nucleus accumbens cocaine-amphetamine regulated transcript mediates food intake during novelty conflict.

Authors:  P R Burghardt; D M Krolewski; K E Dykhuis; J Ching; A M Pinawin; S L Britton; L G Koch; S J Watson; H Akil
Journal:  Physiol Behav       Date:  2016-02-27

8.  Gene expression differences in mice divergently selected for methamphetamine sensitivity.

Authors:  Abraham A Palmer; Miguel Verbitsky; Rathi Suresh; Helen M Kamens; Cheryl L Reed; Na Li; Sue Burkhart-Kasch; Carrie S McKinnon; John K Belknap; T Conrad Gilliam; Tamara J Phillips
Journal:  Mamm Genome       Date:  2005-05       Impact factor: 2.957

9.  Cocaine- and amphetamine-regulated transcript (CART) signaling within the paraventricular thalamus modulates cocaine-seeking behaviour.

Authors:  Morgan H James; Janine L Charnley; Emma Jones; Emily M Levi; Jiann Wei Yeoh; Jamie R Flynn; Douglas W Smith; Christopher V Dayas
Journal:  PLoS One       Date:  2010-09-23       Impact factor: 3.240

10.  Regulation of CART peptide expression by CREB in the rat nucleus accumbens in vivo.

Authors:  George A Rogge; Douglas C Jones; Thomas Green; Eric Nestler; Michael J Kuhar
Journal:  Brain Res       Date:  2008-11-14       Impact factor: 3.252
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