| Literature DB >> 14698613 |
James M Smith1, Peter A Koopman.
Abstract
Recent findings relating to SOX transcription factors indicate that defects in organogenesis can be caused not only by impairment of the biochemical properties of transcription factors but also, in some cases, by deficient nuclear import. In addition, experimentally interfering with the nuclear export signals of some SOX factors has now been found to cause developmental defects. Controlling the balance of nuclear import and export might be a common means by which transcription factor activity can be regulated during development, and defects in these processes might underlie a broader spectrum of inherited developmental disorders.Entities:
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Year: 2004 PMID： 14698613 DOI： 10.1016/j.tig.2003.11.007
Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639