| Literature DB >> 14698479 |
Jun Sato1, Morihiko Aoyama, Masahiro Yamazaki, Satoshi Okumura, Ken Takahashi, Megumi Funakubo, Kazue Mizumura.
Abstract
To examine the effects of change in meteorological parameters on pain-related behaviors in a simulated arthritic condition, rats with an injection of complete Freund's adjuvant into the tibio-tarsal joint were exposed to low barometric pressure (20 mmHg below the natural atmospheric pressure) and low ambient temperature (7 degrees C lower than 22 degrees C) in a climate-controlled room. When the arthritic rats were exposed to these environments, the already increased number of hindpaw withdrawals in response to noxious mechanical stimulation (hyperalgesia) was further increased, and a hindpaw withdrawal response to innocuous mechanical stimulation (allodynia) began to occur. Such exposures did not influence any of the pain-related behaviors of the control rats. These results show that lowering barometric pressure and ambient temperature within the range of natural environmental fluctuation intensify pain in arthritic rats.Entities:
Mesh：
Year: 2004 PMID： 14698479 DOI： 10.1016/j.neulet.2003.09.057
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046