Literature DB >> 14698200

2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors.

Koc-Kan Ho1, Kenneth C Appell, John J Baldwin, Adolph C Bohnstedt, Guizhen Dong, Tao Guo, Robert Horlick, Khondaker R Islam, Steven G Kultgen, Christopher M Masterson, Edward McDonald, Kirk McMillan, J Richard Morphy, Zoran Rankovic, Hardy Sundaram, Maria Webb.   

Abstract

Structure-activity studies on benzamide 1 obtained from library screening led to the discovery of a novel series of potent and selective glycine transporter type-2 inhibitors.

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Year:  2004        PMID: 14698200     DOI: 10.1016/j.bmcl.2003.09.080

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

Review 1.  Inhibition of Glycine Re-Uptake: A Potential Approach for Treating Pain by Augmenting Glycine-Mediated Spinal Neurotransmission and Blunting Central Nociceptive Signaling.

Authors:  Christopher L Cioffi
Journal:  Biomolecules       Date:  2021-06-10
  1 in total

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