| Literature DB >> 14698192 |
Stephen D Lindell1, Oswald Ort, Peter Lümmen, Robert Klein.
Abstract
Potent new inhibitors of NADH:ubiquinone oxidoreductase (complex I) have been designed, with the help of molecular modelling, by hybridisation of known complex I inhibitors with inhibitors of cytochrome c oxidoreductase. The most interesting compound was the chromone 7 which was a selective inhibitor of complex I (IC(50) 15 nM) and showed acaricidal activity against spider mites.Entities:
Mesh：
Substances：
Year: 2004 PMID： 14698192 DOI： 10.1016/j.bmcl.2003.10.022
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823