| Literature DB >> 14698180 |
Ichiro Hayakawa1, Rieko Shioya, Toshinori Agatsuma, Hidehiko Furukawa, Shunji Naruto, Yuichi Sugano.
Abstract
Based on the structure of 4-hydroxy-3-methyl-6-phenylbenzofuran-2-carboxylic acid ethyl ester (1), which exhibits selective cytotoxicity against a tumorigenic cell line, (2,4-dimethoxyphenyl)-(4-hydroxy-3-methyl-6-phenylbenzofuran-2-yl)-methanone (18m) was designed and synthesized as a biologically stable derivative containing no ester group. Although the potency of 18m was almost the same as our initial hit compound 1, 18m is expected to last longer in the human body as an anticancer agent.Entities:
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Year: 2004 PMID： 14698180 DOI： 10.1016/j.bmcl.2003.10.039
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823