Literature DB >> 14698171

1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.

Conrad Kunick1, Kathrin Lauenroth, Maryse Leost, Laurent Meijer, Thomas Lemcke.   

Abstract

Kenpaullone derivatives with a modified parent ring system were synthesized in order to develop kinase inhibitors with enhanced selectivity. Among the novel structures, 1-azakenpaullone was found to act as a selective GSK-3beta versus CDK1 inhibitor. The charge distribution within the 1-azakenpaullone molecule is discussed as a possible explanation for the enhanced GSK-3beta selectivity of 1-azakenpaullone compared to other paullone derivatives.

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Year:  2004        PMID： 14698171     DOI： 10.1016/j.bmcl.2003.10.062

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  49 in total

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5.  A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta.

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Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

Review 9.  Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis.

Authors:  P H Sugden; S J Fuller; S C Weiss; A Clerk
Journal:  Br J Pharmacol       Date:  2008-01-21       Impact factor: 8.739

10.  Involvment of cytosolic and mitochondrial GSK-3beta in mitochondrial dysfunction and neuronal cell death of MPTP/MPP-treated neurons.

Authors:  Agnès Petit-Paitel; Frédéric Brau; Julie Cazareth; Joëlle Chabry
Journal:  PLoS One       Date:  2009-05-11       Impact factor: 3.240
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