| Literature DB >> 14698170 |
Alistair H Bingham1, Richard J Davenport, Lewis Gowers, Roland L Knight, Christopher Lowe, David A Owen, David M Parry, Will R Pitt.
Abstract
A novel series of aminopyrimidine IKK2 inhibitors have been developed which show excellent in vitro inhibition of this enzyme and good selectivity over the IKK1 isoform. The relative potency and selectivity of these compounds has been rationalized using QSAR and structure-based modelling.Entities:
Mesh：
Substances：
Year: 2004 PMID： 14698170 DOI： 10.1016/j.bmcl.2003.10.047
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823