| Literature DB >> 14698153 |
Toshio Nakamura1, Hiroyuki Kakinuma, Hiroki Umemiya, Hideaki Amada, Noriyuki Miyata, Kazuo Taniguchi, Kagumi Bando, Masakazu Sato.
Abstract
In a previous paper, we reported that an imidazole derivative 1 exhibited a potent inhibitory activity of 20-HETE synthase (1; IC(50) value of 5.7 nM), but this compound also exhibited little selectivity for cytochrome P450s (CYPs). We examined some derivatives of imidazole 1 which had an amino group on the side chain, and found that a dimethylaminohexyloxy derivative (3g; IC(50) value of 8.8 nM) showed potent and selective inhibitory activity.Entities:
Mesh：
Substances：
Year: 2004 PMID： 14698153 DOI： 10.1016/j.bmcl.2003.11.005
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823