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Literature DB >> 14698148

4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor.

Shigeo Ueda¹, Hideo Terauchi, Akihiro Yano, Motoharu Ido, Masashi Matsumoto, Motoji Kawasaki.

Abstract

In our search for a novel class of inducible nitric oxide synthase (iNOS) inhibitors, 1,3-oxazolidin-2-imine was found to weakly inhibit iNOS. Further modifications of this compound resulted in a remarkable increase in both the in vivo and in vitro inhibitory activity and selectivity for iNOS.

Entities: Chemical Gene

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Year: 2004 PMID： 14698148 DOI： 10.1016/j.bmcl.2003.11.010

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

7 in total

1. Enantiomeric impurities in chiral synthons, catalysts, and auxiliaries. Part 3.

Authors: Ke Huang; Zachary S Breitbach; Daniel W Armstrong
Journal: Tetrahedron Asymmetry Date: 2006-10-27

Review 2. Isoselenocyanates: a powerful tool for the synthesis of selenium-containing heterocycles.

Authors: Dinesh Ramesh Garud; Mamoru Koketsu; Hideharu Ishihara
Journal: Molecules Date: 2007-03-17 Impact factor: 4.411

3. Design of benzene-1,2-diamines as selective inducible nitric oxide synthase inhibitors: a combined de novo design and docking analysis.

Authors: Sandrea M Francis; Amit Mittal; Manishika Sharma; Prasad V Bharatam
Journal: J Mol Model Date: 2008-01-12 Impact factor: 1.810

4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor.

1. Enantiomeric impurities in chiral synthons, catalysts, and auxiliaries. Part 3.

Review 2. Isoselenocyanates: a powerful tool for the synthesis of selenium-containing heterocycles.

3. Design of benzene-1,2-diamines as selective inducible nitric oxide synthase inhibitors: a combined de novo design and docking analysis.

Review 4. Recent advances toward improving the bioavailability of neuronal nitric oxide synthase inhibitors.

5. Cyclization-carbonylation-cyclization coupling reaction of propargyl ureas with palladium(II)-bisoxazoline catalyst.

6. Visible-light promoted three-component tandem reaction to synthesize difluoromethylated oxazolidin-2-imine.

7. Synthesis of Chiral Allylic Esters by Using the New Recyclable Chiral Heterogeneous Oxazoline-Based Catalysts.