| Literature DB >> 14697885 |
William J Burke1, Shu Wen Li, Hyung D Chung, David A Ruggiero, Bruce S Kristal, Eugene M Johnson, Patricia Lampe, Vijaya B Kumar, Mark Franko, Evelyn A Williams, Daniel S Zahm.
Abstract
The monoamine oxidase (MAO) metabolites of norepinephrine (NE) or epinephrine (EPI) and of dopamine (DA) are 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) and 3,4-dihydroxyphenylacetaldehyde (DOPAL), respectively. The toxicity of these catecholamine (CA) MAO metabolites was predicted over 50 years ago. However, until our recent chemical synthesis of these CA aldehyde metabolites, the hypothesis about their toxicity could not be tested. The present paper reviews recent knowledge gained about these compounds. Topics to be reviewed include: chemical synthesis and properties of DOPEGAL and DOPAL; in vitro and in vivo toxicity of CA aldehydes; subcellular mechanisms of toxicity; free radical formation by DOPEGAL versus DOPAL; mechanisms of accumulation of CA aldehydes in Alzheimer's disease (AD) and Parkinson's disease (PD) and potential therapeutic targets in Alzheimer's disease and Parkinson's disease.Entities:
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Year: 2004 PMID： 14697885 DOI： 10.1016/S0161-813X(03)00090-1
Source DB: PubMed Journal: Neurotoxicology ISSN： 0161-813X Impact factor: 4.294