PURPOSE: The objective of this study was to evaluate the qualitative and quantitative differences that could appear in newly formed peri-implant bone around Screw-Vent implants placed in rabbit tibiae when treated with local administration of growth hormone (GH). MATERIALS AND METHODS: Eight New Zealand rabbits were randomly divided into 2 groups: the experimental group, which received 4 IU of GH in the form of lyophilized powder added to the ostectomy site before implant placement, and the control group, which did not receive GH before implant placement. Animals were sacrificed 2 weeks later, and histologic sections were obtained for histomorphometry and observation under light microscopy. RESULTS: The sections in the GH-treated group presented enhanced growth of new trabeculae from the periosteal tissue, and the bone-to-implant contact in the experimental group was significantly greater (P < .05). DISCUSSION: Local administration of GH stimulated a more dramatic effect than that seen previously with systemic GH administration, prompting growth from both the periosteum and endosteum. CONCLUSIONS: Local administration of GH at the time of implant placement could enhance peri-implant bone reaction.
PURPOSE: The objective of this study was to evaluate the qualitative and quantitative differences that could appear in newly formed peri-implant bone around Screw-Vent implants placed in rabbit tibiae when treated with local administration of growth hormone (GH). MATERIALS AND METHODS: Eight New Zealand rabbits were randomly divided into 2 groups: the experimental group, which received 4 IU of GH in the form of lyophilized powder added to the ostectomy site before implant placement, and the control group, which did not receive GH before implant placement. Animals were sacrificed 2 weeks later, and histologic sections were obtained for histomorphometry and observation under light microscopy. RESULTS: The sections in the GH-treated group presented enhanced growth of new trabeculae from the periosteal tissue, and the bone-to-implant contact in the experimental group was significantly greater (P < .05). DISCUSSION: Local administration of GH stimulated a more dramatic effect than that seen previously with systemic GH administration, prompting growth from both the periosteum and endosteum. CONCLUSIONS: Local administration of GH at the time of implant placement could enhance peri-implant bone reaction.
Authors: Oscar G Bodelón; Celia Clemente; Miguel Angel Alobera; Soledad Aguado-Henche; María Lorenza Escudero; María Cristina García Alonso Journal: Int J Implant Dent Date: 2016-07-21
Authors: J López-Quiles; A Forteza-López; M Montiel; C Clemente; J-A Fernández-Tresguerres; I Fernández-Tresguerres Journal: Med Oral Patol Oral Cir Bucal Date: 2019-09-01
Authors: Jesús Á F Tresguerres; Isabel Fernández-Tresguerres; José Viña; Lisa Rancan; Sergio D Paredes; Beatriz Linillos-Pradillo; Elena Vara Journal: Int J Mol Sci Date: 2022-07-16 Impact factor: 6.208