| Literature DB >> 14695816 |
Anne-Marie Faucher1, Peter W White, Christian Brochu, Chantal Grand-Maître, Jean Rancourt, Gulrez Fazal.
Abstract
The Boehringer Ingelheim compound collection was screened for inhibitors of the ATPase activity of human papillomavirus E1 helicase to develop antiviral agents that inhibit human papillomavirus (HPV) DNA replication. This screen led to the discovery of (biphenyl-4-sulfonyl)acetic acid 1, which inhibits the ATPase activity of HPV type 6 E1 helicase with a low micromolar IC(50) value. A hit-to-lead exercise rapidly converted 1 into a low nanomolar lead series.Entities:
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Year: 2004 PMID： 14695816 DOI： 10.1021/jm034206x
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446