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Literature DB >> 14695813

The discovery of ezetimibe: a view from outside the receptor.

John W Clader¹.

Abstract

Mesh：

Substances：

Year: 2004 PMID： 14695813 DOI： 10.1021/jm030283g

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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33 in total

1. Fluorine bonding enhances the energetics of protein-lipid binding in the gas phase.

Authors: Lan Liu; Nobar Jalili; Alyson Baergen; Simon Ng; Justin Bailey; Ratmir Derda; John S Klassen
Journal: J Am Soc Mass Spectrom Date: 2014-05 Impact factor: 3.109

Review 2. Protein mediators of sterol transport across intestinal brush border membrane.

Authors: J Mark Brown; Liqing Yu
Journal: Subcell Biochem Date: 2010

Review 3. Intestinal nuclear receptors in HDL cholesterol metabolism.

Authors: Chiara Degirolamo; Carlo Sabbà; Antonio Moschetta
Journal: J Lipid Res Date: 2014-07-28 Impact factor: 5.922

4. Efficacy of ezetimibe is not related to NPC1L1 gene polymorphisms in a pilot study of Chilean hypercholesterolemic subjects.

Authors: Tomás Zambrano; Nicolás Saavedra; Fernando Lanas; José Caamaño; Luis A Salazar
Journal: Mol Diagn Ther Date: 2015-02 Impact factor: 4.074

5. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).

Authors: Margarita Garcia-Calvo; JeanMarie Lisnock; Herbert G Bull; Brian E Hawes; Duane A Burnett; Matthew P Braun; James H Crona; Harry R Davis; Dennis C Dean; Patricia A Detmers; Michael P Graziano; Meredith Hughes; D Euan Macintyre; Anthony Ogawa; Kim A O'neill; Sai Prasad N Iyer; Diane E Shevell; Marsha M Smith; Yui S Tang; Amanda M Makarewicz; Feroze Ujjainwalla; Scott W Altmann; Kevin T Chapman; Nancy A Thornberry
Journal: Proc Natl Acad Sci U S A Date: 2005-05-31 Impact factor: 11.205

The discovery of ezetimibe: a view from outside the receptor.

1. Fluorine bonding enhances the energetics of protein-lipid binding in the gas phase.

Review 2. Protein mediators of sterol transport across intestinal brush border membrane.

Review 3. Intestinal nuclear receptors in HDL cholesterol metabolism.

4. Efficacy of ezetimibe is not related to NPC1L1 gene polymorphisms in a pilot study of Chilean hypercholesterolemic subjects.

5. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).

6. Effect of ezetimibe on incretin secretion in response to the intestinal absorption of a mixed meal.

Review 7. Systematizing serendipity for cardiovascular drug discovery.

Review 8. Zebrafish as tools for drug discovery.

9. Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption.

Review 10. Inhibition of cholesterol absorption: targeting the intestine.