Literature DB >> 14695809

Reversal of fluconazole resistance in multidrug efflux-resistant fungi by the Dysidea arenaria sponge sterol 9alpha,11alpha-epoxycholest-7-ene-3beta,5alpha,6alpha,19-tetrol 6-acetate.

Melissa R Jacob1, Chowdhury Faiz Hossain, Kaleem A Mohammed, Troy J Smillie, Alice M Clark, Larry A Walker, Dale G Nagle.   

Abstract

The sponge sterol 9alpha,11alpha-epoxycholest-7-ene-3beta,5alpha,6alpha,19-tetrol 6-acetate (ECTA) (1) is the first marine natural product to reverse fluconazole resistance mediated by a Candida albicans MDR efflux pump. The IC(50) of fluconazole is decreased from 300 to 8.5 microM (35-fold enhancement) when combined with 1(3.8 microM). A revised C-6 configuration of 1 is established.

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Year:  2003        PMID： 14695809     DOI： 10.1021/np030317n

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

Review 1.  Marine pharmacology in 2003-4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Mark T Hamann
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2007-02-09       Impact factor: 3.228

2.  Capisterones A and B, which enhance fluconazole activity in Saccharomyces cerevisiae, from the marine green alga Penicillus capitatus.

Authors:  Xing-Cong Li; Melissa R Jacob; Yuanqing Ding; Ameeta K Agarwal; Troy J Smillie; Shabana I Khan; Dale G Nagle; Daneel Ferreira; Alice M Clark
Journal:  J Nat Prod       Date:  2006-04       Impact factor: 4.050

3.  Reversal of fluconazole resistance by sulfated sterols from the marine sponge Topsentia sp.

Authors:  Jessica A Digirolamo; Xing-Cong Li; Melissa R Jacob; Alice M Clark; Daneel Ferreira
Journal:  J Nat Prod       Date:  2009-08       Impact factor: 4.050

4.  Chemosensitization as a means to augment commercial antifungal agents.

Authors:  Bruce C Campbell; Kathleen L Chan; Jong H Kim
Journal:  Front Microbiol       Date:  2012-02-29       Impact factor: 5.640

5.  Exploring the molecular basis of antifungal synergies using genome-wide approaches.

Authors:  Ameeta K Agarwal; Siddharth K Tripathi; Tao Xu; Melissa R Jacob; Xing-Cong Li; Alice M Clark
Journal:  Front Microbiol       Date:  2012-03-27       Impact factor: 5.640

6.  Synthesis and Inhibitory Activity of Machaeridiol-Based Novel Anti-MRSA and Anti-VRE Compounds and Their Profiling for Cancer-Related Signaling Pathways.

Authors:  Mallika Kumarihamy; Siddharth Tripathi; Premalatha Balachandran; Bharathi Avula; Jianping Zhao; Mei Wang; Maria M Bennett; Jin Zhang; Mary A Carr; K Michael Lovell; Ocean I Wellington; Mary E Marquart; N P Dhammika Nanayakkara; Ilias Muhammad
Journal:  Molecules       Date:  2022-10-05       Impact factor: 4.927
  6 in total

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