| Literature DB >> 14695796 |
Paul R Graupner1, Andy Carr, Erin Clancy, Jeffrey Gilbert, Karen L Bailey, Jo-Anne Derby, B Clifford Gerwick.
Abstract
Field isolates of Phoma macrostoma were obtained from diseased Canada thistle growing in several geographically diverse regions. Bleaching and chlorotic symptoms were present on the infected plants. The isolates grown in liquid culture were found to produce phytotoxic metabolites which also caused bleaching when applied foliarly to several broadleaf species. Bioassay-directed isolation led to the discovery of macrocidins A and B, the first representatives of a new family of cyclic tetramic acids. This new chemotype may offer significant potential as a template for herbicide design.Entities:
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Year: 2003 PMID： 14695796 DOI： 10.1021/np030193e
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050