Literature DB >> 14695510

Chemical strategies for activity-based proteomics.

Anna E Speers1, Benjamin F Cravatt.   

Abstract

The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address this problem, chemical approaches have been introduced that utilize small-molecule probes to profile dynamics in enzyme activity in complex proteomes. These strategies for activity-based protein profiling enable both the discovery and functional analysis of enzymes associated with human disease.

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Year:  2004        PMID： 14695510     DOI： 10.1002/cbic.200300721

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  42 in total

1.  Activity-based probes for the proteomic profiling of metalloproteases.

Authors:  Alan Saghatelian; Nadim Jessani; Arul Joseph; Mark Humphrey; Benjamin F Cravatt
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-25       Impact factor: 11.205

2.  A chemical proteomic probe for detecting dehydrogenases: catechol rhodanine.

Authors:  Xia Ge; Daniel S Sem
Journal:  Methods Mol Biol       Date:  2012

3.  Affinity-based profiling of dehydrogenase subproteomes.

Authors:  Xia Ge; Daniel S Sem
Journal:  Methods Mol Biol       Date:  2012

4.  A tandem orthogonal proteolysis strategy for high-content chemical proteomics.

Authors:  Anna E Speers; Benjamin F Cravatt
Journal:  J Am Chem Soc       Date:  2005-07-20       Impact factor: 15.419

5.  Proteomic profiling of metalloprotease activities with cocktails of active-site probes.

Authors:  Stephan A Sieber; Sherry Niessen; Heather S Hoover; Benjamin F Cravatt
Journal:  Nat Chem Biol       Date:  2006-03-26       Impact factor: 15.040

Review 6.  Advances and challenges in liquid chromatography-mass spectrometry-based proteomics profiling for clinical applications.

Authors:  Wei-Jun Qian; Jon M Jacobs; Tao Liu; David G Camp; Richard D Smith
Journal:  Mol Cell Proteomics       Date:  2006-08-03       Impact factor: 5.911

7.  Activity-based probes for proteomic profiling of histone deacetylase complexes.

Authors:  Cleo M Salisbury; Benjamin F Cravatt
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-16       Impact factor: 11.205

8.  Evaluation of alpha,beta-unsaturated ketone-based probes for papain-family cysteine proteases.

Authors:  Zhimou Yang; Marko Fonović; Steven H L Verhelst; Galia Blum; Matthew Bogyo
Journal:  Bioorg Med Chem       Date:  2008-03-02       Impact factor: 3.641

9.  An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-dihydroxy-2,3-pentanedione analogues.

Authors:  Colin A Lowery; Junguk Park; Gunnar F Kaufmann; Kim D Janda
Journal:  J Am Chem Soc       Date:  2008-06-25       Impact factor: 15.419

Review 10.  Enzymatic pathways that regulate endocannabinoid signaling in the nervous system.

Authors:  Kay Ahn; Michele K McKinney; Benjamin F Cravatt
Journal:  Chem Rev       Date:  2008-04-23       Impact factor: 60.622
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