Literature DB >> 14695063

Description of a putative type I secretion system in Legionella pneumophila.

Sebastian Jacobi1, Klaus Heuner.   

Abstract

Here we describe the first putative type I secretion system of L. pneumophila. The lssXYZABD locus was found to be present in all L. pneumophila strains tested so far. The LssB and LssD proteins are homologues to the proteins of type I secretion systems of Vibrio cholerae and Salmonella typhi. The expression of the gene locus was analysed by RT-PCR. Three polycistronic transcripts could be identified. Comparison of the lss locus of L. pneumophila Philadelphia I with that of L. pneumophila Corby revealed protein identities of 97 to 99%, except for LssE proteins that were only 78.6% identical. Computer analysis of the amino acid sequence of LssE identified it as a putative signalling protein.

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Year:  2003        PMID： 14695063     DOI： 10.1078/1438-4221-00276

Source DB:  PubMed          Journal:  Int J Med Microbiol        ISSN： 1438-4221            Impact factor:   3.473


  16 in total

Review 1.  Molecular pathogenesis of infections caused by Legionella pneumophila.

Authors:  Hayley J Newton; Desmond K Y Ang; Ian R van Driel; Elizabeth L Hartland
Journal:  Clin Microbiol Rev       Date:  2010-04       Impact factor: 26.132

2.  Life Stage-specific Proteomes of Legionella pneumophila Reveal a Highly Differential Abundance of Virulence-associated Dot/Icm effectors.

Authors:  Philipp Aurass; Thomas Gerlach; Dörte Becher; Birgit Voigt; Susanne Karste; Jörg Bernhardt; Katharina Riedel; Michael Hecker; Antje Flieger
Journal:  Mol Cell Proteomics       Date:  2015-11-06       Impact factor: 5.911

3.  A Legionella pneumophila peptidyl-prolyl cis-trans isomerase present in culture supernatants is necessary for optimal growth at low temperatures.

Authors:  Maria A Söderberg; Nicholas P Cianciotto
Journal:  Appl Environ Microbiol       Date:  2007-12-28       Impact factor: 4.792

4.  Legionella pneumophila type II secretome reveals unique exoproteins and a chitinase that promotes bacterial persistence in the lung.

Authors:  Sruti DebRoy; Jenny Dao; Maria Söderberg; Ombeline Rossier; Nicholas P Cianciotto
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-05       Impact factor: 11.205

5.  Legionella pneumophila strain 130b possesses a unique combination of type IV secretion systems and novel Dot/Icm secretion system effector proteins.

Authors:  Gunnar N Schroeder; Nicola K Petty; Aurélie Mousnier; Clare R Harding; Adam J Vogrin; Bryan Wee; Norman K Fry; Timothy G Harrison; Hayley J Newton; Nicholas R Thomson; Scott A Beatson; Gordon Dougan; Elizabeth L Hartland; Gad Frankel
Journal:  J Bacteriol       Date:  2010-09-10       Impact factor: 3.490

6.  Functional type 1 secretion system involved in Legionella pneumophila virulence.

Authors:  Fabien Fuche; Anne Vianney; Claire Andrea; Patricia Doublet; Christophe Gilbert
Journal:  J Bacteriol       Date:  2014-11-24       Impact factor: 3.490

7.  Virulence factors encoded by Legionella longbeachae identified on the basis of the genome sequence analysis of clinical isolate D-4968.

Authors:  Natalia A Kozak; Meghan Buss; Claressa E Lucas; Michael Frace; Dhwani Govil; Tatiana Travis; Melissa Olsen-Rasmussen; Robert F Benson; Barry S Fields
Journal:  J Bacteriol       Date:  2009-12-11       Impact factor: 3.490

8.  Cloning and characterization of the gene encoding the major cell-associated phospholipase A of Legionella pneumophila, plaB, exhibiting hemolytic activity.

Authors:  Antje Flieger; Kerstin Rydzewski; Sangeeta Banerji; Markus Broich; Klaus Heuner
Journal:  Infect Immun       Date:  2004-05       Impact factor: 3.441

9.  Legionella pneumophila secretes an endoglucanase that belongs to the family-5 of glycosyl hydrolases and is dependent upon type II secretion.

Authors:  Meghan M Pearce; Nicholas P Cianciotto
Journal:  FEMS Microbiol Lett       Date:  2009-09-21       Impact factor: 2.742

10.  The type II secretion system of Legionella pneumophila elaborates two aminopeptidases, as well as a metalloprotease that contributes to differential infection among protozoan hosts.

Authors:  Ombeline Rossier; Jenny Dao; Nicholas P Cianciotto
Journal:  Appl Environ Microbiol       Date:  2007-12-14       Impact factor: 4.792
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