Paratesticular mesothelial proliferations.

Varied mesothelial proliferations are found around the testes. Benign reactive mesothelial proliferations in hydrocoeles may be very florid and histologically worrisome, but these can usually be separated from malignant mesotheliomas of the tunica vaginalis because they are confined to a sharply demarcated zone near the luminal surface. In addition, benign inflamed hydrocoeles tend to show a distinct zonation with cellular areas near the luminal surface and more fibrotic areas beneath. The proliferating mesothelial cells in benign reactions often form lines that are parallel to the surface of the hydrocoele. Malignant mesotheliomas of the tunica vaginalis are usually grossly visible as single or multiple nodules. Histologically, they show an epithelial- or mixed epithelial- and sarcomatous-morphologic image, with evidence of stromal invasion. Well-differentiated papillary mesotheliomas are usually solitary exophytic nodules with a distinctive morphologic appearance and benign course, but they must be carefully separated from malignant mesotheliomas with a focally exophytic papillary growth pattern. By definition, well-differentiated papillary mesotheliomas do not exhibit stromal invasion. Peritesticular adenomatoid tumors are also very common; they are benign circumscribed cellular nodules with an appearance comparable to that of adenomatoid tumors in other body locations such as the uterine serosa.