| Literature DB >> 1469449 |
K Nakahara1, M Kuriyama, H Yoshidome, K Nagata, T Nagado, M Nakagawa, K Arimura, I Higuchi, M Osame.
Abstract
We induced experimental myopathy in rabbits by giving simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor. After oral administration of simvastatin (50 mg/kg/day) for 2 weeks, serum CK was elevated in 5 of 7 rabbits; degenerating or necrotic fibers were seen in 3 rabbits. Using electromyography, myotonic discharges were found in the 2 rabbits examined. The combination of myotonic discharges, necrosis and raised serum CK levels suggests that the myopathy was induced by lesions of the muscle surface membrane.Entities:
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Year: 1992 PMID： 1469449 DOI： 10.1016/0022-510x(92)90273-n
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181