William T Cefalu1. 1. University of Vermont College of Medicine, Burlington, Vermont, USA. cefalu@pbrc.edu
Abstract
OBJECTIVE: To comprehensively review the progress to date on the development of alternative routes for insulin delivery. RESEARCH DESIGN AND METHODS: Study data were collected through a Medline review. RESULTS: Proof of principle has been established for many routes of administration including dermal, nasal, oral, buccal, and pulmonary insulin delivery. CONCLUSIONS: Of all the approaches to date, pulmonary delivery appears to be most feasible. Ongoing phase III studies will ultimately determine safety, tolerability, and efficacy before approval for clinical use.
OBJECTIVE: To comprehensively review the progress to date on the development of alternative routes for insulin delivery. RESEARCH DESIGN AND METHODS: Study data were collected through a Medline review. RESULTS: Proof of principle has been established for many routes of administration including dermal, nasal, oral, buccal, and pulmonary insulin delivery. CONCLUSIONS: Of all the approaches to date, pulmonary delivery appears to be most feasible. Ongoing phase III studies will ultimately determine safety, tolerability, and efficacy before approval for clinical use.
Authors: V Akbari; F Hendijani; A Feizi; J Varshosaz; Z Fakhari; S Morshedi; S A Mostafavi Journal: J Endocrinol Invest Date: 2015-06-24 Impact factor: 4.256
Authors: Dario Pitocco; Leonello Fuso; Emanuele G Conte; Francesco Zaccardi; Carola Condoluci; Giuseppe Scavone; Raffaele A Incalzi; Giovanni Ghirlanda Journal: Rev Diabet Stud Date: 2012-05-10