Literature DB >> 14693843

Clinical phenotype of haemoglobin Q-H disease.

K F S Leung, E S K Ma, A Y Y Chan, L C Chan.   

Abstract

Seven patients of Chinese origin who had haemoglobin (Hb) Q-H disease were studied. They were found to have a similar clinical phenotype to that of patients with deletional Hb H disease, who have a near identical genotypic configuration. The complete absence of Hb A in Hb Q-H disease and the similar clinical phenotype to deletional Hb H disease lends support to the observation that Hb Q-Thailand shares similar functional properties with Hb A.

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Year:  2004        PMID： 14693843      PMCID： PMC1770185          DOI： 10.1136/jcp.57.1.81

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  5 in total

1.  The genetic basis of Hb Q-H disease.

Authors:  D R Higgs; D M Hunt; H C Drysdale; J B Clegg; L Pressley; D J Weatherall
Journal:  Br J Haematol       Date:  1980-11       Impact factor: 6.998

2.  The alpha-globin gene adjacent to the gene for HbQ-alpha 74 Asp replaced by His is deleted, but not that adjacent to the gene for HbG-alpha 30 Glu replaced by Gln; three-fourths of the alpha-globin genes are deleted in HbQ-alpha-thalassemia.

Authors:  L E Lie-Injo; A M Dozy; Y W Kan; M Lopes; D Todd
Journal:  Blood       Date:  1979-12       Impact factor: 22.113

3.  Genetic and clinical features of hemoglobin H disease in Chinese patients.

Authors:  F E Chen; C Ooi; S Y Ha; B M Cheung; D Todd; R Liang; T K Chan; V Chan
Journal:  N Engl J Med       Date:  2000-08-24       Impact factor: 91.245

4.  Further cases of Hb Q-H disease (Hb Q-alpha thalassemia).

Authors:  R P Pillay; V Thuraisingham
Journal:  Blood       Date:  1966-12       Impact factor: 22.113

5.  Molecular analysis of Hb Q-H disease and Hb Q-Hb E in a Singaporean family.

Authors:  J Tan; J S Tay; Y C Wong; S K Kham; N Bte Abd Aziz; S H Teo; H B Wong
Journal:  Southeast Asian J Trop Med Public Health       Date:  1995       Impact factor: 0.267
  5 in total
  3 in total

1.  A laboratory strategy for genotyping haemoglobin H disease in the Chinese.

Authors:  Amy Yuk-Yin Chan; Chi-Chiu So; Edmond Shiu-Kwan Ma; Li-Chong Chan
Journal:  J Clin Pathol       Date:  2006-10-03       Impact factor: 3.411

2.  Clinico-Hematological Profile of Hb Q India: An Uncommon Hemoglobin Variant.

Authors:  Aradhana Harrison; Ranjeet Singh Mashon; Naveen Kakkar; Sheila Das
Journal:  Indian J Hematol Blood Transfus       Date:  2017-08-18       Impact factor: 0.900

3.  Detection of compound heterozygous of hb constant spring and hb q-Thailand by capillary electrophoresis and high performance liquid chromatography.

Authors:  Sakorn Pornprasert; Manoo Punyamung
Journal:  Indian J Hematol Blood Transfus       Date:  2014-06-13       Impact factor: 0.900
  3 in total

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