Literature DB >> 14693557

FKS1 mutations responsible for selective resistance of Saccharomyces cerevisiae to the novel 1,3-beta-glucan synthase inhibitor arborcandin C.

Takao Ohyama1, Shunichi Miyakoshi, Fujio Isono.   

Abstract

Arborcandin C is a novel antibiotic with potent antifungal activity that inhibits 1,3-beta-glucan synthase in fungi. We examined spontaneous Saccharomyces cerevisiae mutants which are selectively resistant to arborcandin C and revealed that a single amino acid replacement in Fks1p of Asn(470) with Lys or of Leu(642) with Ser confers selective resistance on Fks1p mutants.

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Year:  2004        PMID： 14693557      PMCID： PMC310202          DOI： 10.1128/AAC.48.1.319-322.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Pneumocandins from Zalerion arboricola. V. Glutamic acid- and leucine-derived amino acids in pneumocandin A0 (L-671,329) and distinct origins of the substituted proline residues in pneumocandins A0 and B0.

Authors:  A A Adefarati; O D Hensens; E T Jones; J S Tkacz
Journal:  J Antibiot (Tokyo)       Date:  1992-12       Impact factor: 2.649

2.  Comparison of the in vitro activities of the echinocandin LY303366, the pneumocandin MK-0991, and fluconazole against Candida species and Cryptococcus neoformans.

Authors:  T V Krishnarao; J N Galgiani
Journal:  Antimicrob Agents Chemother       Date:  1997-09       Impact factor: 5.191

3.  In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872).

Authors:  K Bartizal; C J Gill; G K Abruzzo; A M Flattery; L Kong; P M Scott; J G Smith; C E Leighton; A Bouffard; J F Dropinski; J Balkovec
Journal:  Antimicrob Agents Chemother       Date:  1997-11       Impact factor: 5.191

Review 4.  Lipopeptide inhibitors of fungal glucan synthase.

Authors:  M B Kurtz; C M Douglas
Journal:  J Med Vet Mycol       Date:  1997 Mar-Apr

Review 5.  Review: cell wall assembly in yeast.

Authors:  F M Klis
Journal:  Yeast       Date:  1994-07       Impact factor: 3.239

6.  Characterization and gene cloning of 1,3-beta-D-glucan synthase from Saccharomyces cerevisiae.

Authors:  S B Inoue; N Takewaki; T Takasuka; T Mio; M Adachi; Y Fujii; C Miyamoto; M Arisawa; Y Furuichi; T Watanabe
Journal:  Eur J Biochem       Date:  1995-08-01

Review 7.  Antibiotics that inhibit fungal cell wall development.

Authors:  M Debono; R S Gordee
Journal:  Annu Rev Microbiol       Date:  1994       Impact factor: 15.500

8.  The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth.

Authors:  W K Eng; L Faucette; M M McLaughlin; R Cafferkey; Y Koltin; R A Morris; P R Young; R K Johnson; G P Livi
Journal:  Gene       Date:  1994-12-30       Impact factor: 3.688

9.  The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase.

Authors:  C M Douglas; F Foor; J A Marrinan; N Morin; J B Nielsen; A M Dahl; P Mazur; W Baginsky; W Li; M el-Sherbeini
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

10.  Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase.

Authors:  H Qadota; C P Python; S B Inoue; M Arisawa; Y Anraku; Y Zheng; T Watanabe; D E Levin; Y Ohya
Journal:  Science       Date:  1996-04-12       Impact factor: 47.728
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  9 in total

Review 1.  Resistance to echinocandin-class antifungal drugs.

Authors:  David S Perlin
Journal:  Drug Resist Updat       Date:  2007-06-13       Impact factor: 18.500

2.  Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility.

Authors:  Santosh Katiyar; Michael Pfaller; Thomas Edlind
Journal:  Antimicrob Agents Chemother       Date:  2006-08       Impact factor: 5.191

3.  Rapid emergence of echinocandin resistance during Candida kefyr fungemia treatment with caspofungin.

Authors:  A Fekkar; I Meyer; J Y Brossas; E Dannaoui; M Palous; M Uzunov; S Nguyen; V Leblond; D Mazier; A Datry
Journal:  Antimicrob Agents Chemother       Date:  2013-02-25       Impact factor: 5.191

4.  Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates.

Authors:  S Park; R Kelly; J Nielsen Kahn; J Robles; M-J Hsu; E Register; W Li; V Vyas; H Fan; G Abruzzo; A Flattery; C Gill; G Chrebet; S A Parent; M Kurtz; H Teppler; C M Douglas; D S Perlin
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

5.  Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata: implications for echinocandin resistance.

Authors:  Santosh K Katiyar; Ana Alastruey-Izquierdo; Kelley R Healey; Michael E Johnson; David S Perlin; Thomas D Edlind
Journal:  Antimicrob Agents Chemother       Date:  2012-10-01       Impact factor: 5.191

6.  Sequencing of FKS Hot Spot 1 from Saprochaete capitata To Search for a Relationship to Reduced Echinocandin Susceptibility.

Authors:  Inés Arrieta-Aguirre; Pilar Menéndez-Manjón; María Soledad Cuétara; Iñigo Fernández de Larrinoa; Juan Carlos García-Ruiz; María Dolores Moragues
Journal:  Antimicrob Agents Chemother       Date:  2018-01-25       Impact factor: 5.191

7.  Emergence of echinocandin-resistant Candida spp. in a hospital setting: a consequence of 10 years of increasing use of antifungal therapy?

Authors:  A Fekkar; E Dannaoui; I Meyer; S Imbert; J Y Brossas; M Uzunov; G Mellon; S Nguyen; E Guiller; E Caumes; V Leblond; D Mazier; M H Fievet; A Datry
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2014-04-09       Impact factor: 3.267

8.  Role for Fks1 in the intrinsic echinocandin resistance of Fusarium solani as evidenced by hybrid expression in Saccharomyces cerevisiae.

Authors:  Santosh K Katiyar; Thomas D Edlind
Journal:  Antimicrob Agents Chemother       Date:  2009-03-02       Impact factor: 5.191

9.  Benzylic Dehydroxylation of Echinocandin Antifungal Drugs Restores Efficacy against Resistance Conferred by Mutated Glucan Synthase.

Authors:  Dana Logviniuk; Qais Z Jaber; Roman Dobrovetsky; Noga Kozer; Ewa Ksiezopolska; Toni Gabaldón; Shmuel Carmeli; Micha Fridman
Journal:  J Am Chem Soc       Date:  2022-03-29       Impact factor: 15.419
  9 in total

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