| Literature DB >> 14693176 |
Rossana Lombardi1, Veena Chantarangkul, Marco Cattaneo, Armando Tripodi.
Abstract
The measurement of plasma warfarin is required to investigate non-compliance, resistance to anticoagulation, drug metabolism and pharmacokinetic. Methods so far described are based on extraction of warfarin from plasma followed by reversed-phase HPLC. Extraction is the crucial step and may be performed in liquid- or solid-phase. The latter requires the preparation of columns, which makes the procedure variable. We investigated the suitability of the ready-for-use commercial cartridges for sample preparation. The method displayed between-run CV of 11.8%. Recovery was 99%. The coefficients of correlation between warfarin concentration in 50 patients and weekly dosage or INR were 0.55 (p<0.0001) or 0.25 (p=0.079).Entities:
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Year: 2003 PMID： 14693176 DOI： 10.1016/j.thromres.2003.09.006
Source DB: PubMed Journal: Thromb Res ISSN： 0049-3848 Impact factor: 3.944