Literature DB >> 14692532

Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells.

Ruth Gallily1, Tal Even-Chena, Galia Katzavian, Dan Lehmann, Arie Dagan, Raphael Mechoulam.   

Abstract

Two non-psychotropic cannabinoids, cannabidiol (CBD) and cannabidiol-dimethylheptyl (CBD-DMH), induced apoptosis in a human acute myeloid leukemia (AML) HL-60 cell line. Apoptosis was determined by staining with bisBenzimide and propidium iodide. A dose dependent increase of apoptosis was noted, reaching 61 and 43% with 8 microg/ml CBD and 15 microg/ml CBD-DMH, respectively, after a 24 h treatment. Prior exposure of the cells to gamma-irradiation (800 cGy) markedly enhanced apoptosis, reaching values of 93 and 95%, respectively. Human monocytes from normal individuals were resistant to either cannabinoids or gamma-irradiation. Caspase-3 activation was observed after the cannabinoid treatment, and may represent a mechanism for the apoptosis. Our data suggest a possible new approach to treatment of AML.

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Year:  2003        PMID： 14692532     DOI： 10.1080/1042819031000103917

Source DB:  PubMed          Journal:  Leuk Lymphoma        ISSN： 1026-8022


  15 in total

1.  Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice.

Authors:  Ewa Kozela; Nirit Lev; Nathali Kaushansky; Raya Eilam; Neta Rimmerman; Rivka Levy; Avraham Ben-Nun; Ana Juknat; Zvi Vogel
Journal:  Br J Pharmacol       Date:  2011-08       Impact factor: 8.739

Review 2.  Cannabidiol as potential anticancer drug.

Authors:  Paola Massi; Marta Solinas; Valentina Cinquina; Daniela Parolaro
Journal:  Br J Clin Pharmacol       Date:  2013-02       Impact factor: 4.335

3.  The non-psychoactive plant cannabinoid, cannabidiol affects cholesterol metabolism-related genes in microglial cells.

Authors:  Neta Rimmerman; Ana Juknat; Ewa Kozela; Rivka Levy; Heather B Bradshaw; Zvi Vogel
Journal:  Cell Mol Neurobiol       Date:  2011-04-30       Impact factor: 5.046

4.  Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9-tetrahydrocannabinol in BV-2 microglial cells.

Authors:  Ana Juknat; Maciej Pietr; Ewa Kozela; Neta Rimmerman; Rivka Levy; Giovanni Coppola; Daniel Geschwind; Zvi Vogel
Journal:  Br J Pharmacol       Date:  2012-04       Impact factor: 8.739

5.  A Novel Observational Method for Assessing Acute Responses to Cannabis: Preliminary Validation Using Legal Market Strains.

Authors:  L Cinnamon Bidwell; Raeghan Mueller; Sophie L YorkWilliams; Sarah Hagerty; Angela D Bryan; Kent E Hutchison
Journal:  Cannabis Cannabinoid Res       Date:  2018-03-01

Review 6.  Is the cardiovascular system a therapeutic target for cannabidiol?

Authors:  Christopher P Stanley; William H Hind; Saoirse E O'Sullivan
Journal:  Br J Clin Pharmacol       Date:  2013-02       Impact factor: 4.335

7.  Cannabidiol effects on behaviour and immune gene expression in zebrafish (Danio rerio).

Authors:  Hannah M Jensen; Rozalia Korbut; Per W Kania; Kurt Buchmann
Journal:  PLoS One       Date:  2018-07-31       Impact factor: 3.240

Review 8.  Pros and Cons of the Cannabinoid System in Cancer: Focus on Hematological Malignancies.

Authors:  Natasha Irrera; Alessandra Bitto; Emanuela Sant'Antonio; Rita Lauro; Caterina Musolino; Alessandro Allegra
Journal:  Molecules       Date:  2021-06-24       Impact factor: 4.411

9.  Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death.

Authors:  N Rimmerman; D Ben-Hail; Z Porat; A Juknat; E Kozela; M P Daniels; P S Connelly; E Leishman; H B Bradshaw; V Shoshan-Barmatz; Z Vogel
Journal:  Cell Death Dis       Date:  2013-12-05       Impact factor: 8.469

10.  Anti-Inflammatory, Antioxidative, and Hepatoprotective Effects of Trans Δ9-Tetrahydrocannabinol/Sesame Oil on Adjuvant-Induced Arthritis in Rats.

Authors:  Morouj Ismail; Hiba Hasan; Youmna El-Orfali; Hanan Ismail; Ghada Khawaja
Journal:  Evid Based Complement Alternat Med       Date:  2018-06-25       Impact factor: 2.629
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