OBJECTIVE: Since the role of fibrinolytic activity is unclear in coronary artery ectasia, we investigated the entire fibrinolytic activity by a new test, global fibrinolytic capacity (GFC) in the ectasia patients. METHODS AND RESULTS: Thirty-four ectasia patients (18 male, mean age: 58 +/- 8 years) presenting with acute coronary syndrome and 25 controls (14 male, mean age: 56 +/- 9 years) with normal coronary artery were evaluated. GFC, D-dimer and other hemostatic factors were assessed. Clinical characteristics were comparable in both groups. Serum GFC (4.6 +/- 2.1 vs. 3.1 +/- 2.1 microg/ml, p = 0.03) and D-dimer levels (0.69 +/- 0.42 vs. 0.41 +/- 0.38 ng/ml, p = 0.02, respectively) were significantly higher in ectasia patients than in controls. They were also higher in subgroup of patients with myocardial infarction (four patients) compared with other ectasia patients and controls (p = 0.04, 0.01, respectively). Other hemostatic factors were not different in both groups. GFC was correlated with D-dimer (r = 0.76, p = 0.01). CONCLUSION: Our results suggest that fibrinolytic system activation may develop in ectasia patients with acute coronary syndrome. It can be induced by thrombus formation in ectatic segment of coronary artery.
OBJECTIVE: Since the role of fibrinolytic activity is unclear in coronary artery ectasia, we investigated the entire fibrinolytic activity by a new test, global fibrinolytic capacity (GFC) in the ectasiapatients. METHODS AND RESULTS: Thirty-four ectasiapatients (18 male, mean age: 58 +/- 8 years) presenting with acute coronary syndrome and 25 controls (14 male, mean age: 56 +/- 9 years) with normal coronary artery were evaluated. GFC, D-dimer and other hemostatic factors were assessed. Clinical characteristics were comparable in both groups. Serum GFC (4.6 +/- 2.1 vs. 3.1 +/- 2.1 microg/ml, p = 0.03) and D-dimer levels (0.69 +/- 0.42 vs. 0.41 +/- 0.38 ng/ml, p = 0.02, respectively) were significantly higher in ectasiapatients than in controls. They were also higher in subgroup of patients with myocardial infarction (four patients) compared with other ectasiapatients and controls (p = 0.04, 0.01, respectively). Other hemostatic factors were not different in both groups. GFC was correlated with D-dimer (r = 0.76, p = 0.01). CONCLUSION: Our results suggest that fibrinolytic system activation may develop in ectasiapatients with acute coronary syndrome. It can be induced by thrombus formation in ectatic segment of coronary artery.
Authors: M Cushman; R N Lemaitre; L H Kuller; B M Psaty; E M Macy; A R Sharrett; R P Tracy Journal: Arterioscler Thromb Vasc Biol Date: 1999-03 Impact factor: 8.311
Authors: M Nikfardjam; S Graf; R Beckmann; S Hornykewycz; J Koller-Strametz; B R Binder; K Huber Journal: Thromb Haemost Date: 1999-09 Impact factor: 5.249
Authors: Diego Araiza-Garaygordobil; Rodrigo Gopar-Nieto; Daniel Sierra-Lara Martínez; Nallely Belderrain-Morales; Vianney Sarabia-Chao; Diana Laura Alfaro-Ponce; Heriberto Ontiveros-Mercado; Salvador Mendoza-García; Alfredo Altamirano-Castillo; Pablo Martinez-Amezcua; Alejandro Cabello-López; Jose Luis Briseño-De la Cruz; Maximiliano Ruiz-Beltrán; Marco Antonio Martínez-Ríos; Yigal Piña-Reyna; Hector Gonzalez-Pacheco; Alexandra Arias-Mendoza Journal: High Blood Press Cardiovasc Prev Date: 2022-07-29