Literature DB >> 1468981

Epoxomicin, a new antitumor agent of microbial origin.

M Hanada1, K Sugawara, K Kaneta, S Toda, Y Nishiyama, K Tomita, H Yamamoto, M Konishi, T Oki.   

Abstract

An actinomycete strain No. Q996-17 produced a novel compound, epoxomicin, which exhibited in vivo antitumor activity against B16 melanoma. Structural studies indicated that it is a new member of the epoxy-beta-aminoketone group, and is closely related to eponemycin.

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Year:  1992        PMID： 1468981     DOI： 10.7164/antibiotics.45.1746

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  44 in total

1.  The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses.

Authors:  K Schwarz; R de Giuli; G Schmidtke; S Kostka; M van den Broek; K B Kim; C M Crews; R Kraft; M Groettrup
Journal:  J Immunol       Date:  2000-06-15       Impact factor: 5.422

Review 2.  The ubiquitin-proteasome pathway and proteasome inhibitors.

Authors:  J Myung; K B Kim; C M Crews
Journal:  Med Res Rev       Date:  2001-07       Impact factor: 12.944

3.  Total synthesis and absolute stereochemistry of the proteasome inhibitors cystargolides A and B.

Authors:  Rodolfo Tello-Aburto; Liam P Hallada; Doleshwar Niroula; Snezna Rogelj
Journal:  Org Biomol Chem       Date:  2015-09-24       Impact factor: 3.876

4.  Identification of the proteasome inhibitor MG262 as a potent ATP-dependent inhibitor of the Salmonella enterica serovar Typhimurium Lon protease.

Authors:  Hilary Frase; Jason Hudak; Irene Lee
Journal:  Biochemistry       Date:  2006-07-11       Impact factor: 3.162

5.  Nocardia asteroides strain GUH-2 induces proteasome inhibition and apoptotic death of cultured cells.

Authors:  Daniel P Barry; Blaine L Beaman
Journal:  Res Microbiol       Date:  2006-12-15       Impact factor: 3.992

Review 6.  Microbial natural products: molecular blueprints for antitumor drugs.

Authors:  Lesley-Ann Giddings; David J Newman
Journal:  J Ind Microbiol Biotechnol       Date:  2013-09-03       Impact factor: 3.346

Review 7.  Chemical genetics: exploring the role of the proteasome in cell biology using natural products and other small molecule proteasome inhibitors.

Authors:  Kyung Bo Kim; Craig M Crews
Journal:  J Med Chem       Date:  2008-04-05       Impact factor: 7.446

8.  Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells.

Authors:  Elena Lorente; Ruth García; Daniel López
Journal:  J Biol Chem       Date:  2011-09-13       Impact factor: 5.157

9.  Peptide and Peptide-Like Modulators of 20S Proteasome Enzymatic Activity in Cancer Cells.

Authors:  Carlos García-Echeverría
Journal:  Int J Pept Res Ther       Date:  2006-03-04       Impact factor: 1.931

10.  Perturbation of DNA repair pathways by proteasome inhibitors corresponds to enhanced chemosensitivity of cells to DNA damage-inducing agents.

Authors:  Takashi Takeshita; Wenwen Wu; Ayaka Koike; Mamoru Fukuda; Tomohiko Ohta
Journal:  Cancer Chemother Pharmacol       Date:  2009-03-10       Impact factor: 3.333
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